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| Citation | Zhao, K., Harel, A., Stuurman, N., Guedalia, D., Gruenbaum, Y. (1996). Binding of matrix attachment regions to nuclear lamin is mediated by the rod domain and depends on the lamin polymerization state. FEBS Lett. 380(1-2): 161--164. (Export to RIS) | ||
| FlyBase ID | FBrf0087806 | ||
| Publication Type | Research paper | ||
| PubMed ID | 8603728 | ||
| PubMed Abstract | The nuclear matrix maintains specific interactions with genomic DNA at sites known as matrix attachment regions (M/SARs). M/SARs bind in vitro to lamin polymers. We show that the polymerized alpha-helical rod domain of lamin Dm0 provides by itself the specific binding to the ftz M/SAR. In contrast, unpolymerized rod domain does not bind specifically to this M/SAR. Non-specific binding to DNA is also observed with Dm0 containing a point mutation that impairs its ability to polymerize or with the isolated tail domain. These data suggest that the specific binding of lamins to M/SARs requires the rod domain and depends on the lamin polymerization state. | ||
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| Language of Publication | English | ||
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| Publication Type | Journal | ||
| Abbreviation | FEBS Lett. | ||
| Title | FEBS Letters | ||
| Publication Year | 1968- | ||
| ISBN/ISSN | 0014-5793 | ||
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Data from Reference
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