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Citation
Kim, J., Sebring, A., Esch, J.J., Kraus, M.E., Vorwerk, K., Magee, J., Carroll, S.B. (1996). Integration of positional signals and regulation of wing formation and identity by Drosophila vestigial gene.  Nature 382(6587): 133--138.
FlyBase ID
FBrf0088295
Publication Type
Research paper
Abstract

Appendage formation is organized by signals from discrete sources that presumably act upon downstream genes to control growth and patterning. The Drosophila vestigial gene is selectively required for wing-cell proliferation, and is sufficient to induce outgrowths of wing tissue from eyes, legs and antennae. Different signals activate separate enhancers to control vestigial expression: first, in the dorsal/ventral organizer through the Notch pathway, and subsequently, in the developing wing blade by decapentaplegic and a signal from the dorsal/ventral organizer. Signal integration must be a general feature of genes like vestigial, that regulate growth or patterning along more than one axis.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Nature
    Title
    Nature
    Publication Year
    1869-
    ISBN/ISSN
    0028-0836
    Data From Reference
    Alleles (15)
    Genes (14)
    Molecular Constructs (5)
    Molecular Segments (2)
    Sequence Features (2)
    Natural transposons (1)
    Insertions (4)
    Experimental Tools (2)
    Transgenic Constructs (6)