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Kurzik-Dumke, U., Neubauer, M., Debes, A. (1996). Identification of a novel Drosophila melanogaster heat-shock gene, lethal (2) denticleless (l(2)dtl), coding for an 83-kDa protein.  Gene 171(2): 163--170.
FlyBase ID
FBrf0088355
Publication Type
Research paper
Abstract
In this study, we describe the identification of a novel Drosophila melanogaster (Dm) gene, l(2)dtl, characterized by elevated expression under heat-shock (HS) conditions. It encodes a protein of 83 kDa with no homology to known members of the HSP90 family and other proteins. Gene l(2)dtl is located on the right arm of the second chromosome at locus 59F5, close to the tumor suppressor gene l(2)tid, a homolog of the dnaJ encoding a chaperone strongly conserved in evolution. In the following, we present the sequence of l(2)dtl, the putative protein it encodes, and its molecular localization in a closely interspaced gene cluster consisting of at least four nested genes spanning an approximately 10-kb genomic interval. Furthermore, we present the temporal expression of l(2)dtl in the wild type under normal and HS conditions, and describe the isolation and the phenotype of eight embryonic lethal l(2)dtl mutants.
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Gene
    Title
    Gene
    Publication Year
    1976-
    ISBN/ISSN
    0378-1119
    Data From Reference
    Aberrations (2)
    Alleles (13)
    Genes (6)
    Transgenic Constructs (2)