Reference Report

Reference
Citation	Brook, W.J., Cohen, S.M. (1996). Antagonistic interactions between wingless and decapentaplegic responsible for dorsal-ventral pattern in the Drosophila Leg. Science 273(5280): 1373--1377. (Export to RIS)
FlyBase ID	FBrf0089604
Publication Type	Research paper
PubMed ID	8703069
PubMed Abstract	Subdivision of the limb primordia of Drosophila into anterior and posterior compartments triggers cell interactions that pattern the legs and wings. A comparable compartment-based mechanism is used to pattern the dorsal-ventral axis of the wing. Evidence is presented here for a mechanism based on cell interaction, rather than on compartment formation, that distinguishes dorsal from ventral in the leg. Mutual repression by Wingless and Decapentaplegic signaling systems generates a stable regulatory circuit by which each gene maintains its own expression in a spatially restricted domain. Compartment-independent patterning mechanisms may be used by other organisms during development.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Science
Title	Science
Publication Year	1895-
ISBN/ISSN	0036-8075
Data from Reference
Alleles (19)
	Avic\GFP^Scer\UAS.cYa dpp^d6 dpp^d12 dpp^H61 dpp^Scer\UAS.cFa Ecol\lacZ^bi-Pol-1 Ecol\lacZ^dpp.BS3.0 Ecol\lacZ^H15-H-15 Ecol\lacZ^wg-en11 Pka-C1^H2 Scer\FLP1^hs.PG Scer\GAL4^30A Scer\GAL4^bi-omb-Gal4 Scer\GAL4^dpp.blk1 wg^Act5C.PS wg^{l-12.Scer\UAS} wg^l-16 wg^{Scer\FRT.Act5C} wg^Scer\UAS.cLa
Constructs (9)
	P{Act5C(FRT.y⁺)wg.S} P{Act5C(-FRT)wg.S} P{BS3.0} P{GAL4-dpp.blk1} P{hsFLP} P{UAS(-FRT)wg.ts} P{UAS-dpp.BEH1} P{UAS-GFP.Y} P{UAS-wg.L}
Genes (12)
	Avic\GFP bi dpp Ecol\lacZ H15 hh Mad Pka-C1 ptc Scer\FLP1 Scer\GAL4 wg
Insertions (5)
	P{en1}wg^en11 P{GAL4}bi^omb-Gal4 P{GawB}30A P{lacW}bi^Pol-1 P{PZ}H-15