|Citation||Chen, C.M., Freedman, J.A., Bettler, D.R., Manning, S.D., Giep, S.N., Steiner, J., Ellis, H.M. (1996). Polychaetoid is required to restrict segregation of sensory organ precursors from proneural clusters in Drosophila. Mech. Dev. 57(2): 215--227. (Export to RIS)|
|Publication Type||Research paper|
|PubMed Abstract||Reduction of wild-type activity of the polychaetoid (pyd) gene results in formation of extra mechanosensory bristles on the head and notum of adult Drosophila. Loss of pyd function results in decreased ability to restrict sensory organ precursor (SOP) formation to a single cell per proneural cluster. Although the initial proneural cluster pattern of achaete expression is not altered in pyd mutants, extra cells within proneural clusters express the high levels of achaete characteristic of SOPs. This observation suggests that pyd+ functions as a negative regulator of achaete-scute complex expression within the proneural cluster. Synergistic interactions between pyd and Notch, Delta and extramacrochaetae mutations support this model. We also demonstrate that pyd is required for normal eye development.|
What does this section display?
What does this section not display?
This section does not currently display links that were removed or gene model changes.
|All updates||Click here to see a list of all updates to this record from FB2010_08 and on.|
|Language of Publication||English|
|Additional Languages of Abstract|
|Also Published As|
|Title||Mechanisms of Development|
|Data from Reference|