Reference Report

Reference
Citation	Dernburg, A.F., Daily, D.R., Yook, K.J., Corbin, J.A., Sedat, J.W., Sullivan, W. (1996). Selective loss of sperm bearing a compound chromosome in the Drosophila female. Genetics 143(4): 1629--1642. (Export to RIS)
FlyBase ID	FBrf0089628
Publication Type	Research paper
PubMed ID	8844151
PubMed Abstract	The Drosophila compound entire second chromosome, C(2)EN, displays paternal transmission well below Mendelian expectations (NOVITSKI et al. 1981). Because C(2)EN stocks also show higher-than-expected rates of zygotic lethality, it was proposed that this reduced paternal inheritance might be wholly or partially due to postfertilization events. Efforts to investigate this phenomenon have been hampered because the progeny of crosses between C(2)EN-bearing individuals and those with normal karyotypes die during embryogenesis. We have circumvented this obstacle by employing fluorescence in situ hybridization to directly karyotype early embryos from crosses involving C(2)EN-bearing individuals. This analysis reveals that the distortion in paternal transmission is established before fertilization. Moreover, measurement of the sperm ratios within both the male and female reproductive organs demonstrates that C(2)EN-bearing sperm are selectively lost after sperm transfer to the female and before storage of sperm in the seminal receptacles and spermathecae. Our results are consistent with a model of meiotic drive in which aberrations occurring early in meiosis lead ultimately to sperm dysfunction.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Genetics
Title	Genetics
Publication Year	1916-
ISBN/ISSN	0016-6731
Data from Reference
Aberrations (1)
	C(2)EN
Alleles (4)
	b^unspecified bw¹ pr^unspecified sp¹
Balancers (3)
	C(2)EN⁺ C(2)EN-vDa C(2)EN-vNb
Genes (4)
	b bw pr sp