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Citation
Hart, M.C., Wang, L., Coulter, D.E. (1996). Comparison of the structure and expression of odd-skipped and two related genes that encode a new family of zinc finger proteins in Drosophila.  Genetics 144(1): 171--182.
FlyBase ID
FBrf0089674
Publication Type
Research paper
Abstract

The odd-skipped (odd) gene, which was identified on the basis of a pair-rule segmentation phenotype in mutant embryos, is initially expressed in the Drosophila embryo in seven pair-rule stripes, but later exhibits a segment polarity-like pattern for which no phenotypic correlate is apparent. We have molecularly characterized two embryonically expressed odd-cognate genes, sob and bowel (bowl), that encode proteins with highly conserved C2H2 zinc fingers. While the Sob and Bowl proteins each contain five tandem fingers, the Odd protein lacks a fifth (C-terminal) finger and is also less conserved among the four common fingers. Reminiscent of many segmentation gene paralogues, the closely linked odd and sob genes are expressed during embryogenesis in similar striped patterns; in contrast, the less-tightly linked bowl gene is expressed in a distinctly different pattern at the termini of the early embryo. Although our results indicate that odd and sob are more likely than bowl to share overlapping developmental roles, some functional divergence between the Odd and Sob proteins is suggested by the absence of homology outside the zinc fingers, and also by amino acid substitutions in the Odd zinc fingers at positions that appear to be constrained in Sob and Bowl

PubMed ID
PubMed Central ID
PMC1207491 (PMC) (EuropePMC)
DOI
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Secondary IDs
  • FBrf0090600
Language of Publication
English
Additional Languages of Abstract
Parent Publication
Publication Type
Journal
Abbreviation
Genetics
Title
Genetics
Publication Year
1916-
ISBN/ISSN
0016-6731
Data From Reference
Genes (3)