Reference Report

Reference
Citation	Ludlow, C., Choy, R., Blochlinger, K. (1996). Functional analysis of Drosophila and mammalian cut proteins in flies. Dev. Biol. 178(1): 149--159. (Export to RIS)
FlyBase ID	FBrf0089730
Publication Type	Research paper
PubMed ID	8812116
PubMed Abstract	The cut locus acts as a bimodal switch controlling cell fate in the peripheral nervous system of Drosophila and is also required for the development of the wing margin. It encodes a protein, Cut, that contains an atypical homeodomain and three copies of a new motif which can bind DNA in vitro. The human protein CDP and the murine protein Cux have recently been isolated as DNA-binding activities and they are structurally related to Cut. We show that ectopic expression of Cut, CDP, or Cux similarly affects embryonic sensory organ development and can rescue a wing scalloping mutant phenotype associated with loss of cut expression along the prospective wing margins. This suggests that the function of Cut is evolutionarily conserved.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Dev. Biol.
Title	Developmental Biology
Publication Year	1959-
ISBN/ISSN	0012-1606
Data from Reference
Alleles (8)
	ct⁶ ct^db10 ct^Scer\UAS.cLa Ecol\lacZ^A1-2-29 Hsap\CUX1^Scer\UAS.cLa Mmus\Cutl1^Scer\UAS.cLa Scer\GAL4^bbg-C96 Scer\GAL4^h-1J3
Constructs (3)
	P{UAS-ct.L} P{UCDP} P{UCux}
Genes (5)
	ct Ecol\lacZ Hsap\CUX1 Mmus\Cutl1 Scer\GAL4
Insertions (3)
	P{GawB}bbg^C96 P{GawB}h^1J3 P{lacW}A1-2-29