Reference Report

Reference
Citation	Mulligan, P.K., Campos, A.R., Jacobs, J.R. (1996). Mutations in the gene stand still disrupt germ cell differentiation in Drosophila ovaries. Dev. Genet. 18(4): 316--326. (Export to RIS)
FlyBase ID	FBrf0089756
Publication Type	Research paper
PubMed ID	8754283
PubMed Abstract	During oogenesis in Drosophila, germ cells appear in sequential clusters of 16 interconnected cells. The events surrounding the differentiation of these cells are not fully understood. Here we present genetic and morphological analysis of mutations in the gene stand still (stil). Through complementation analyses we have refined the location of this gene to cyological region 49B-C. Our analyses of ovaries from ethylmethane sulfonate (EMS)-induced mutant alleles of this gene suggest that mutations in the stil gene produce a wide range of phenotypic abnormalities, from the absence of germ cells in the most severe alleles, to egg chambers with cytoskeletal defects in the less severe alleles. Our results suggest a role for this gene in specifying or maintaining a cytoskeletal component, with consequences during oogenesis and possibly during germ line sex determination.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Dev. Genet.
Title	Developmental Genetics
Publication Year	1979-1999
ISBN/ISSN	0192-253X
Data from Reference
Aberrations (6)
	Df(2R)CX1 Df(2R)en30 Df(2R)vg135 Df(2R)vg-B Df(2R)vg-C In(2R)vg^U
Alleles (5)
	exu^{NGE.T:Avic\GFP} ms(3)neo79¹ stil¹ stil² stil³
Constructs (1)
	P{GFP-exu}
Genes (4)
	exu ms(3)neo79 stil T:Avic\GFP
Insertions (1)
	P{hsneo}ms(3)neo79¹