Reference Report

Reference
Citation	Nakao, K., Campos-Ortega, J.A. (1996). Persistent expression of genes of the Enhancer of Split complex suppresses neural development in Drosophila. Neuron 16(2): 275--286. (Export to RIS)
FlyBase ID	FBrf0090006
Publication Type	Research paper
PubMed ID	8789943
PubMed Abstract	The segregation of neural and epidermal progenitors in Drosophila requires the activity of transcription factors encoded by the proneural genes and the genes of the E(SPL)-C. Persistent expression of two genes of the E(SPL)-C suppresses neural development. Embryos exhibit conspicuous central neural hypoplasia and lack sensory organs; imaginal sensory organs are also affected. Suppression of neural development is associated with suppression of the activity of proneural genes. DNA binding is not essential for this effect. Large cells with characteristics of neuroblasts segregate normally in embryos, but these cells fail to express various markers, and the segregated cells and/or their progeny eventually die. These findings indicate that proneural and E(spl) proteins exert antagonistic functions.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Neuron
Title	Neuron
Publication Year	1988-
ISBN/ISSN	0896-6273
Data from Reference
Aberrations (2)
	Df(1)260-1 Df(3R)gro^b32.2
Alleles (13)
	E(spl)m5-HLH^Scer\UAS.cNa E(spl)m8-HLH^{1,bd-.Scer\UAS} E(spl)m8-HLH^1,bd- E(spl)m8-HLH^Scer\UAS.cNa E(spl)m8-HLH^{Scer\UAS.T:Zzzz\FLAG} Ecol\lacZ^neur-A101 l(1)sc^Scer\UAS.cCa Scer\GAL4^da.G32 Scer\GAL4^h-540.3 Scer\GAL4^Kr.PM Scer\GAL4^ptc-559.1 Scer\GAL4^sca-537.4 w^+mC
Constructs (5)
	P{E(spl)^bd-UAST} P{GAL4-Kr.C} P{HLHm5-UAST} P{UAS-^Nflag-E(spl)} P{UAS-E(spl).N}
Genes (11)
	ase E(spl)m5-HLH E(spl)m8-HLH Ecol\lacZ l(1)sc neur sca Scer\GAL4 sna T:Zzzz\FLAG w
Insertions (4)
	P{GawB}h-540.3 P{GawB}ptc^559.1 P{GawB}sca^537.4 P{lArB}neur^A101