Reference Report

Reference
Citation	Adamson, A.L., Shearn, A. (1996). Molecular genetic analysis of Drosophila ash2, a member of the trithorax group required for imaginal disc pattern formation. Genetics 144(2): 621--633. (Export to RIS)
FlyBase ID	FBrf0090426
Publication Type	Research paper
External Crossreferences
PubMed ID	8889525
PubMed Abstract	The ash2 gene is a member of the trithorax group of genes whose products function to maintain active transcription of homeotic selector genes. Mutations in ash2 cause the homeotic transformations expected for a gene in this group but, in addition, cause a variety of pattern formation defects that are not necessarily expected. The ash2 gene is located in cytogenetic region 96A17-19 flanked by slowpoke and tolloid and is included in a cosmid that contains part of slowpoke. The ash2 transcript is 2.0 kb and is present throughout development. The ASH2 protein predicted from the nucleotide sequence of the open reading frame has a putative double zinc-finger domain, called a PHD finger, that is present not only in the products of other trithorax group genes such as TRX and ASH1, but also in the product of a Polycomb group gene, PCL. Polyclonal antibodies directed against ASH2 detect the protein in imaginal discs and in the nuclei of salivary gland and fat body cells. On immunoblots these affinity-purified antibodies detect a 70-kDa protein in larvae and a 53-kDa protein in pupae.
BIOSIS ID	99230676
Zoological Record ID
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Language of Publication	English
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ISBN
Parent Publication
Publication Type	Journal
Abbreviation	Genetics
Title	Genetics
Editors
Publication Year	1916-
ISBN/ISSN	0016-6731
Data from Reference
Aberrations (4)
	Df(3R)ash¹⁸ Df(3R)crb87-5 Df(3R)tld-γ1 T(Y;3)A117
Alleles (26)
	Antp^73b Antp^Ns ash2¹ ash2² ash2³ ash2⁴ ash2⁶ ash2⁷ ash2⁸ ash2⁹ ash2¹⁰ ash2¹¹ ash2¹² ash2¹³ ash2¹⁴ ash2¹⁵ ash2¹⁶ ash2¹⁷ ash2¹⁸ Ecol\lacZ^dpp.BS3.0 Ecol\lacZ^neur-A101 Ecol\lacZ^wg-en11 l(3)96Aa¹⁴ l(3)96Ab^299.1 l(3)96Ac^291.6 l(3)96Ad^291.3
Constructs (1)
	P{BS3.0}
Genes (9)
	Antp ash2 Ecol\lacZ l(3)96Aa l(3)96Ab l(3)96Ac l(3)96Ad slo tld
Insertions (2)
	P{en1}wg^en11 P{lArB}neur^A101