|Citation||Bashaw, G.J., Baker, B.S. (1996). Dosage compensation and chromatin structure in Drosophila. Curr. Opin. Genet. Dev. 6(4): 496--501. (Export to RIS)|
|PubMed Abstract||The past year has brought significant advances in our understanding of the male-specific lethal (msl genes and dosage compensation in Drosophila. The molecular characterization of the msl-2 gene has, to a great extent, solved the question of how msl-mediated dosage compensation is restricted to males. Molecular analyses of the msl genes have substantiated the proposal that the MSL proteins function as a multimeric complex to mediate dosage compensation. The finding that MSL-2 protein has a RING finger and the demonstration that an insulator protein facilitates the dosage compensation of X-linked genes inserted into the autosomes have opened promising avenues to identify the cis-acting dosage-compensation determinants.|
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|Language of Publication||English|
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|Abbreviation||Curr. Opin. Genet. Dev.|
|Title||Current Opinion in Genetics and Development|
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