Reference Report

Reference
Citation	Chen, Y., Struhl, G. (1996). Dual roles for Patched in sequestering and transducing Hedgehog. Cell 87(3): 553--563. (Export to RIS)
FlyBase ID	FBrf0090495
Publication Type	Research paper
PubMed ID	8898207
PubMed Abstract	Secreted proteins of the Hedgehog (Hh) family have diverse organizing roles in animal development. Recently, a serpentine protein Smoothened (Smo) has been proposed as a Hh receptor. Here, we present evidence that implicates another multiple-pass transmembrane protein, Patched (Ptc), in Hh reception and suggests a novel signal transduction mechanism in which Hh binds to Ptc, or a Ptc-Smo complex, and thereby induces Smo activity. Our results also show that Ptc limits the range of Hh action; we provide evidence that high levels of Ptc induced by Hh serve to sequester any free Hh and therefore create a barrier to its further movement.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Cell
Title	Cell
Publication Year	1974-
ISBN/ISSN	0092-8674
Data from Reference
Alleles (24)
	Ecol\lacZ^arm.PV Ecol\lacZ^dpp-10638 Ecol\lacZ^dpp.BS3.0 Ecol\lacZ^en-Xho25 Ecol\lacZ^hh-P30 Ecol\lacZ^ptc.PG Hsp70Ab^polyA Pka-C1^E95 ptc¹⁶ ptc¹⁸ ptc^S2 ptc^{Scer\FRT.Rnor\CD2.αTub84B.hs3'UTR} ptc^{Scer\FRT.Rnor\CD2.αTub84B} ptc^{Scer\FRT.Scer\UAS} ptc^Scer\UAS.cCa ptc^αTub84B.PCa ptc^αTub84B.PCb Rnor\CD2^A902 Rnor\CD2^hs.PJ ry^+t7.2 Scer\GAL4^Bx-MS1096 smo³ w^+mC y^+t7.7
Constructs (10)
	P{arm-lacZ.V} P{BS3.0} P{hsp70-CD2.J} P{ptcA-lacZ} P{Tubα1-ptc-hsp70.3'UTR} P{UAS(FRT.y⁺CD2)ptc.C} P{UAS(-FRT)ptc.C} P{αTub84B(FRT.y⁺CD2)ptc-hsp70.3'UTR} P{αTub84B(FRT.y⁺CD2)ptc-αTub84B.3'UTR} P{αTub84B(-FRT)ptc-αTub84B.3'UTR}
Genes (13)
	ci dpp Ecol\lacZ hh Hsp70Ab Pka-C1 ptc Rnor\CD2 ry Scer\GAL4 smo w y
Insertions (4)
	P{en-lacZ(Xho)}en^Xho25 P{GawB}Bx^MS1096 P{PZ}dpp¹⁰⁶³⁸ P{PZ}hh^P30