|Citation||Chen, Y., Struhl, G. (1996). Dual roles for Patched in sequestering and transducing Hedgehog. Cell 87(3): 553--563. (Export to RIS)|
|Publication Type||Research paper|
|PubMed Abstract||Secreted proteins of the Hedgehog (Hh) family have diverse organizing roles in animal development. Recently, a serpentine protein Smoothened (Smo) has been proposed as a Hh receptor. Here, we present evidence that implicates another multiple-pass transmembrane protein, Patched (Ptc), in Hh reception and suggests a novel signal transduction mechanism in which Hh binds to Ptc, or a Ptc-Smo complex, and thereby induces Smo activity. Our results also show that Ptc limits the range of Hh action; we provide evidence that high levels of Ptc induced by Hh serve to sequester any free Hh and therefore create a barrier to its further movement.|
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|Language of Publication||English|
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