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Citation
Dowse, H., Ringo, J., Power, J., Johnson, E., Kinney, K., White, L. (1995). A congenital heart defect in Drosophila caused by an action-potential mutation.  J. Neurogenet. 10(3): 153--168.
FlyBase ID
FBrf0090531
Publication Type
Research paper
Abstract

The mutation no action potential (nap) induces arrhythmia in the heartbeat of Drosophila melanogaster larvae at temperatures above 20 degrees C; heartbeat becomes normally rhythmic again after a shift back to 20 degrees C. For this phenotype, napa is almost completely recessive to the wild type, napa also reduces the temperature-sensitivity of heart rate over a wide range of temperature, for this phenotype, napa is dominant over the wild type, napa causes reversible paralysis in adults by epistatic effects on the expression of paralyrica, a gene encoding a voltage-dependent sodium channel. However, the paramutation, which induces paralysis in adults at 29 degrees C, has no effect on larval heartbeat at temperatures between 20 degrees and 37.5 degrees C. The period gene, contra earlier reports, has no effect on heartbeat.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    J. Neurogenet.
    Title
    Journal of Neurogenetics
    Publication Year
    1983-
    ISBN/ISSN
    0167-7063
    Data From Reference
    Aberrations (3)
    Alleles (6)
    Genes (7)
    Transgenic Constructs (1)