Reference Report

Reference
Citation	Kolodziej, P.A., Timpe, L.C., Mitchell, K.J., Fried, S.R., Goodman, C.S., Yeh-Jan, L., Jan, Y.N. (1996). frazzled encodes a Drosophila member of the DCC immunoglobulin subfamily and is required for CNS and motor axon guidance. Cell 87(2): 197--204. (Export to RIS)
FlyBase ID	FBrf0090650
Publication Type	Research paper
PubMed ID	8861904
PubMed Abstract	We have identified a Drosophila member of the deleted in colorectal cancer (DCC) gene family. The frazzled gene encodes transmembrane proteins that contain four immunoglobulin C2 type domains, six fibronectin type III repeats, and a cytoplasmic domain of 278 amino acids. Like vertebrate members of the DCC family, Frazzled is expressed on axons in the embryonic central nervous system and on motor axons in the periphery. Frazzled is also expressed on epidermis and gut epithelium. Null mutants in frazzled are defective in axon guidance in the central nervous system and in motor axon guidance and targeting in the periphery. The phenotypes strongly resemble those of a deletion of the two Drosophila Netrin genes. We have rescued the frazzled CNS and motor axon defects by expressing Frazzled specifically in neurons; expression in target tissues does not rescue the phenotype. These data, together with vertebrate studies showing binding of DCC to netrin, suggest that Frazzled may function in vivo as a receptor or component of a receptor mediating Netrin-dependent axon guidance.
DOI
Related Publication(s)
Review	Monitor. Anonymous, 1997, Trends Genet. 13(1): 12 [FBrf0092773] Headlines. Anonymous, 1997, Trends Cell Biol. 7(2): 47 [FBrf0099712]
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Secondary IDs
Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Cell
Title	Cell
Publication Year	1974-
ISBN/ISSN	0092-8674
Data from Reference
Aberrations (3)
	Df(2R)vg135 In(2LR)O T(2;3)fra¹
Alleles (9)
	Ecol\lacZ²⁷⁶ fra¹ fra² fra³ fra⁴ fra^49B fra^Scer\UAS.cKa Scer\GAL4^how-24B Scer\GAL4^insc-Mz1407
Balancers (2)
	CyO CyO-276
Constructs (1)
	P{UAS-fra}
Genes (5)
	Ecol\lacZ fra NetA NetB Scer\GAL4
Insertions (4)
	P{GawB}how^24B P{GawB}insc^Mz1407 P{lacW}fra^49B P{lacZ-un3}276