|Citation||Neuman-Silberberg, F.S., Schupbach, T. (1996). The Drosophila TGF--like protein Gurken: expression and cellular localization during Drosophila oogenesis. Mech. Dev. 59(2): 105--113. (Export to RIS)|
|Publication Type||Research paper|
|PubMed Abstract||The establishment of anterior-posterior and dorsal-ventral polarity of the Drosophila egg and embryo depends on the function of the genes gurken, cornichon and Egfr (Drosophila epidermal growth factor receptor homolog). These genes encode components of a signal transduction pathway that transmits information between the germline cells and the somatic follicle cells of the ovary. gurken encodes a transforming growth factor-alpha-like protein and is a putative germline ligand of the Egfr present on the follicle cells. In mid-oogenesis the gurken transcript becomes spatially localized to the future dorsal-anterior cortex of the oocyte. To analyze the distribution pattern of Gurken protein we prepared antibodies against Gurken. We describe here the distribution pattern of the Gurken protein in wild-type ovaries and in ovaries from a number of dorsal-ventral patterning mutants. By immunoblotting we detect one major form of the Gurken protein, which likely corresponds to the unprocessed protein.|
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|Language of Publication||English|
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|Also Published As|
|Title||Mechanisms of Development|
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