Reference Report

Reference
Citation	Rulifson, E.J., Micchelli, C.A., Axelrod, J.D., Perrimon, N., Blair, S.S. (1996). wingless refines its own expression domain on the Drosophila wing margin. Nature 384(6604): 72--74. (Export to RIS)
FlyBase ID	FBrf0090775
Publication Type	Research paper
PubMed ID	8900280
PubMed Abstract	The imaginal discs of Drosophila, which give rise to the adult appendages, are patterned during a period of intense cell proliferation. The specification of differing regions occurs in some cases by subdividing the disc epithelium into lineage compartments. However, in most cases precise boundaries are formed between different cell types without early compartmentalization. One such boundary occurs between the wingless (wg)-expressing cells of the wing margin and the adjacent proneural cells, which give rise to margin sensory bristles. Here we show that this boundary arises in part by a mechanism of 'self-refinement', by which wingless protein (Wg) represses wg expression in adjacent cells. Cells unable to receive the Wg signal do not resolve the boundary between wg-expressing and proneural cells.
DOI
Related Publication(s)
Erratum	wingless refines its own expression domain on the Drosophila wing margin. Rulifson et al., 1996, Nature 384(6609): 597 [FBrf0092861]
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Secondary IDs
Language of Publication	English
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Publication Type	Journal
Abbreviation	Nature
Title	Nature
Publication Year	1869-
ISBN/ISSN	0028-0836
Data from Reference
Alleles (12)
	dsh³ dsh⁷⁵ dsh^Scer\UAS.cAa N¹⁰⁸¹ ovo^svb-2 Scer\FLP1^hs.PG Scer\GAL4^en-e16E wg^17en40cP1 wg^hs.PN wg^l-8 wg^l-12 wg^l-17
Constructs (2)
	P{HS-wg} P{UAS-dsh.A}
Genes (7)
	arm dsh N ovo Scer\FLP1 Scer\GAL4 wg
Insertions (1)
	P{en2.4-GAL4}e16E