Reference Report

Reference
Citation	Sanson, B., White, P., Vincent, J.P. (1996). Uncoupling cadherin-based adhesion from wingless signalling in Drosophila. Nature 383(6601): 627--630. (Export to RIS)
FlyBase ID	FBrf0090785
Publication Type	Research paper
PubMed ID	8857539
PubMed Abstract	The Wnt genes encode secreted glycoproteins used in intercellular communication at multiple steps during development. Signalling by Wingless, the Drosophila Wnt-1 homologue, requires the activity of Armadillo, the homologue of vertebrate beta-catenin, which is a component of the cadherin/catenin complex at adherens junctions. The genetic link between wingless and armadillo suggests that cell fate specification and cell-cell adhesion might be controlled concurrently. For instance, in one extreme view, Wingless could specify cell fate entirely by modulating cell adhesion. Alternatively, it might signal independently of adherens junctions. To distinguish between these alternatives, we have expressed two polypeptides that have opposite effects on cadherin-dependent adhesion: full-length Drosophila E-cadherin and a dominant-negative truncated form. We found that overexpression of either construct mimics wingless phenotypes, thereby uncoupling changes in adhesion from signalling effects. We demonstrate that both constructs titrate Armadillo from a 'signalling' pool which is functionally distinct from the junctional pool.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Nature
Title	Nature
Publication Year	1869-
ISBN/ISSN	0028-0836
Data from Reference
Alleles (14)
	aos::shg^{i.Scer\UAS.T:Hsap\MYC} arm¹ arm^Scer\UAS.cSa Scer\FLP1^βTub85D.PS Scer\GAL4^arm.PS Scer\GAL4^{arm.T:Hsim\VP16} Scer\GAL4^en-e16E Scer\GAL4^{Scer\FRT.arm.T:Hsim\VP16} shg¹ shg² shg^Scer\UAS.cSa w^+mC w^+mW.hs y^+t7.7
Constructs (11)
	P{GAL4-arm.S} P{GAL4-arm(FRT.y⁺).VP16} P{GAL4-arm(-FRT).VP16} P{UAS-arm.S} P{UAS-shg.CAD} P{UAS-shg.CADⁱ} P{βTub85D-FLP} pP{GAL4-arm.S} pP{UAS-arm.S} pP{UAS-shg.CAD} pP{UAS-shg.CADⁱ}
Genes (11)
	aos aos::shg arm Scer\FLP1 Scer\GAL4 shg T:Hsap\MYC T:Hsim\VP16 w wg y
Insertions (1)
	P{en2.4-GAL4}e16E