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| Citation | Schnepp, B., Grumbling, G., Donaldson, T., Simcox, A. (1996). Vein is a novel component in the Drosophila epidermal growth factor receptor pathway with similarity to the neuregulins. Genes Dev. 10(18): 2302--2313. (Export to RIS) | ||
| FlyBase ID | FBrf0090788 | ||
| Publication Type | Research paper | ||
| PubMed ID | 8824589 | ||
| PubMed Abstract | The activation signal from tyrosine kinase receptors, such as the epidermal growth factor receptor (EGFR), is relayed via a highly conserved intracellular pathway involving Ras, Raf, and MAPK. In Drosophila, the EGFR and components of the intracellular pathway are broadly expressed, yet receptor activation evokes tissue-specific cell responses. Extracellular events that lead to receptor activation are one mechanism by which signaling is modulated. Here we show molecular and genetic evidence that Drosophila vein (vn) encodes a candidate EGFR ligand and that vn expression is spatially restricted. Consequently, vn may promote tissue-specific receptor activation. Unlike two other ligands, Gurken (Grk) and Spitz (Spi), which are transforming growth factor alpha-like proteins, Vn has both an immunoglobulin-like and an EGF-like domain. This combination of domains mirrors those in the vertebrate neuregulins that bind EGFR relatives. | ||
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| Language of Publication | English | ||
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Parent Publication
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| Publication Type | Journal | ||
| Abbreviation | Genes Dev. | ||
| Title | Genes & Development | ||
| Publication Year | 1987- | ||
| ISBN/ISSN | 0890-9369 | ||
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Data from Reference
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| Aberrations (6)
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| Alleles (22)
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| Constructs (1)
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| Genes (5)
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| Insertions (5)
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