Reference Report

Reference
Citation	Sluss, H.K., Han, Z., Barrett, T., Goberdhan, D.C.I., Wilson, C., Davis, R.J., Ip, Y.T. (1996). A JNK signal transduction pathway that mediates morphogenesis and an immune response in Drosophila. Genes Dev. 10(21): 2745--2758. (Export to RIS)
FlyBase ID	FBrf0090803
Publication Type	Research paper
PubMed ID	8946915
PubMed Abstract	The Drosophila MAP kinase DJNK is a homolog of the mammalian c-Jun amino-terminal kinase (JNK). Mutations in the DJNK gene correspond to the complementation group basket. DJNK is phosphorylated and activated by the Drosophila MAP kinase kinase HEP. Substrates of DJNK include the transcription factor DJun. DJNK participates in multiple physiological processes. Exposure to endotoxic lipopolysaccharide initiates an insect immune response and leads to DJNK activation. In addition, embryos lacking DJNK are defective in dorsal closure, a process in which the lateral epithelial cells migrate over the embryo and join at the dorsal midline. These data demonstrate that the DJNK signal transduction pathway mediates an immune response and morphogenesis in vivo.
DOI
Related Publication(s)
Erratum	A JNK signal transduction pathway that mediates morphogenesis and an immune response in Drosophila. Sluss et al., 1997, Genes Dev. 11(4): 541 [FBrf0092866]
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Secondary IDs
Language of Publication	English
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Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Genes Dev.
Title	Genes & Development
Publication Year	1987-
ISBN/ISSN	0890-9369
Data from Reference
Aberrations (6)
	Df(2L)flp147E Df(2L)flp170B Df(2L)J77 Df(2L)J106 Df(2L)JR1 In(3LR)TM6
Alleles (7)
	bsk¹ bsk² bsk^{Act5C.T:Zzzz\FLAG} bsk^hs.PS chico¹ w^+mC y⁺
Balancers (1)
	TM6-y⁺
Constructs (1)
	P{DJNK}
Genes (10)
	bsk chico hep J Jra me31B rl T:Zzzz\FLAG w y