Reference Report

Reference
Citation	Verheyen, E.M., Purcell, K.J., Fortini, M.E., Artavanis-Tsakonas, S. (1996). Analysis of dominant enhancers and suppressors of activated Notch in Drosophila. Genetics 144(3): 1127--1141. (Export to RIS)
FlyBase ID	FBrf0090844
Publication Type	Research paper
PubMed ID	8913755
PubMed Abstract	The Notch receptor controls cell fate decisions throughout Drosophila development. Truncated, ligand-independent forms of this protein delay or block differentiation. We have previously shown that expression of the intracellular domain of the receptor under the control of the sevenless enhancer/promoter induces a rough eye phenotype in the adult fly. Analysis of the resultant cellular transformations suggested that this form of Notch acts as a constitutively activated receptor. To identify gene products that interact with Notch, a second-site mutagenesis screen was performed to isolate enhancers and suppressors of the eye phenotype caused by expression of these activated Notch molecules. We screened 137,000 mutagenized flies and recovered 290 dominant modifiers. Many new alleles of previously identified genes were isolated, as were mutations defining novel loci that may function in the Notch signaling pathway. We discuss the data with respect to known features of Notch receptor signaling and Drosophila eye development.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Genetics
Title	Genetics
Publication Year	1916-
ISBN/ISSN	0016-6731
Data from Reference
Aberrations (11)
	Df(2L)b84h50 Df(2L)el80f1 Df(2L)el88 Df(2L)prd1.7 Df(2R)PK1 Df(2R)Pu-D17 Df(3R)3450 Df(3R)Bd Df(3R)Dl-X43 Df(3R)Espl22 T(2;3)E-3911
Alleles (190)
	anon-IX^eA13 anon-IX^eJ11 anon-VIII^eBB2 anon-VIII^eEM1 anon-XII^eCP9 anon-XII^eCP12 anon-XII^eCR3 anon-XII^eN4 anon-XIII^eAH7 anon-XIII^eAV9 anon-XIV^sC12 anon-XIV^sU2 anon-XV^3-eAF1 anon-XV^4-eCN5 anon-XV^eAN4 anon-XVI^1-eCN5 anon-XVI^sAL4 anon-XVIII^sCI1 anon-XVIII^sCM4 anon-XX^eAK12 anon-XX^eAV4 anon-XXIII^eBD1 anon-XXIII^eBD4 anon-XXIII^eQ7 anon-XXIV^eBG4 anon-XXIV^eBU1 Dl^5F Dl^9P Dl^eA1 Dl^eA7 Dl^eAA5 Dl^eAB2 Dl^eAC2 Dl^eAH5 Dl^eAI3 Dl^eAI9 Dl^eAK2 Dl^eAL3 Dl^eAN9 Dl^eAN13 Dl^eAR3 Dl^eAR5 Dl^eAR6 Dl^eAT2 Dl^eAU2 Dl^eAU4 Dl^eAU8 Dl^eAV12 Dl^eAY2 Dl^eAZ1 Dl^eAZ5a Dl^eAZ18 Dl^eB3 Dl^eBE1 Dl^eBX1 Dl^eC5 Dl^eCX2 Dl^eCY4 Dl^eD6 Dl^eDL3 Dl^eDW2 Dl^eE4 Dl^eK1 Dl^eK12 Dl^eM1 Dl^eM4 Dl^eM9 Dl^eO4 Dl^eP10 Dl^eQ3 dx¹ dx^eAN1 Egfr^E1 Egfr^E3 Egfr^eAO6 Egfr^eAW2 Egfr^eBP3 Egfr^eCH2 Egfr^eCP7 Egfr^eCS15 Egfr^eEM2 Egfr^eEP3 Egfr^eG1 Egfr^f6 Egm¹ eH3^eH3 eK6^eK6 eZ6^eZ6 gl^eP2a H¹ ifx^eAQ3 ifx^eCO3 kis⁰²⁵³² kis⁰⁷⁸¹² kis^eAL7 kis^eB15 kis^eBA8 kis^eBD10 kis^eCM2 kis^eCV2 kis^eDO1 kis^eDV6 kis^eE4 kis^eEA2 kis^eG2 kis^eI7 kis^eJ6 kis^eK15 kis^eP18 kis^rL432 kis^s3527 kis^s4771 kis^s4793 kis^S lola²²¹¹² lola^eAK4 lola^eCF3 lola^eCQ1 lola^eDZ6 lola^eES2a-spont mam¹⁰ mam^eA1 mam^eA6 mam^eAO1 mam^eC16 mam^eF14 mam^sAX8 mng^eD9 N^act.sev N^Ax-9 N^Ax-E2 N^Ax-sAR5 N^eAS7b N^eU10 N^nucl.sev nmo^adk1 nmo^adk2 pnt^eAL13 pnt^eAS7a pnt^eT13 Rab6^eAM4 Rab6^eAS1 Rab6^eER1 S^eAA2 S^eAD7 S^eAG4 S^eAG5 S^eAL11 S^eAN5 S^eAO3 S^eAQ3 S^eAS5 S^eCJ9 S^eDO3 S^eE6 S^eO7 S^eQ10 S^eT6 S^eW4 sAB1^sAB1 sAM16^sAM16 sca² sca^eCS5 sng^sAK12 sng^sDX1 sng^sK1 sng^sU4 Sos^e2H Sos^eCN6 Sos^eCS3 Sos^eDN4 Sos^eJ2 Sos^eN6 stg² stg^eAS7a stg^sCG4 stg^sM3 Su(H)^eBC11 Su(H)^IB115 Su(H)^sA21 Su(H)^sK2 Su(H)^sO10 Su(H)^T4 Tbp^E-3911 Tbp^sBT1 Tbp^sC4 Tbp^sEU4 Tbp^sI10 Tbp^sO12 Tbp^sP5a
Constructs (2)
	P{sev-N^act} P{sev-Notch^nucl}
Genes (39)
	anon-IX anon-VIII anon-XII anon-XIII anon-XIV anon-XV anon-XVI anon-XVIII anon-XX anon-XXIII anon-XXIV Dl dx E(spl)m8-HLH Egfr Egm eH3 eK6 eZ6 gl H ifx kis lola mam mng N nmo pnt Rab6 S sAB1 sAM16 sca sng Sos stg Su(H) Tbp
Insertions (6)
	P{lacW}kis^s3527 P{lacW}kis^s4771 P{lacW}kis^s4793 P{PZ}kis⁰²⁵³² P{PZ}kis⁰⁷⁸¹² P{PZ}kis^rL432