Reference Report

Reference
Citation	Chen, E.H., Baker, B.S. (1997). Compartmental organization of the Drosophila genital imaginal discs. Development 124(1): 205--218. (Export to RIS)
FlyBase ID	FBrf0091028
Publication Type	Research paper
PubMed ID	9006081
PubMed Abstract	We have investigated the anterior and posterior compartmental organization of the genital imaginal disc. Unlike the thoracic discs, the genital disc is a compound disc consisting of three primordia--the female genital, male genital, and anal primordia. Here we provide evidence that each primordium is divided into anterior and posterior compartments. Genes that are known to be expressed in compartment-specific manners in other discs (engrailed, hedgehog, patched, decapentaplegic, wingless and cubitus interruptus) are expressed in analogous patterns in each primordium of the genital disc. Specifically, engrailed and cubitus interruptus are expressed in complementary domains, while patched, decapentaplegic and wingless are expressed along the border between the two domains. Mitotic clones induced at the beginning of the second larval instar do not cross the boundary between the engrailed-expressing and cubitus interruptus-expressing domains, indicating that these domains are true genetic compartments. Furthermore, we examined the phenotypes of mutant clones of the cAMP-dependent protein kinase A and engrailed-invected, genes that are known to play compartment-specific functions in other discs. These experiments demonstrate that the anterior/posterior patterning functions of these genes are conserved in the genital disc. The adult clonal phenotypes of protein kinase A and engrailed-invected mutants also provide a more detailed map of the adult genitalia and analia with respect to the anterior/posterior compartmental subdivision. Our results lead us to propose a new model to describe the anterior and posterior compartmental organization of the genital disc.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Aberrations (1)
	Df(2R)en^E
Alleles (10)
	Ecol\lacZ^ci.7.1 Ecol\lacZ^dpp.BS3.0 Ecol\lacZ^en-Xho25 Ecol\lacZ^hh-P30 Ecol\lacZ^ptc-AT90 Ecol\lacZ^wg-P999 Pka-C1^B3 wg^l-12 wg^l-16 wg^l-17
Constructs (2)
	P{7.1-ci} P{BS3.0}
Genes (9)
	ci dpp Ecol\lacZ en hh inv Pka-C1 ptc wg
Insertions (4)
	P{en-lacZ(Xho)}en^Xho25 P{lacZ}P999 P{lacZ-un2}ptc-AT90 P{PZ}hh^P30