Reference Report

Reference
Citation	Fambrough, D., Goodman, C.S. (1996). The Drosophila beaten path gene encodes a novel secreted protein that regulates defasciculation at motor axon choice points. Cell 87(6): 1049--1058. (Export to RIS)
FlyBase ID	FBrf0091058
Publication Type	Research paper
External Crossreferences
PubMed ID	8978609
PubMed Abstract	In the Drosophila embryo, at specific choice points along the major motor nerves, subsets of motor axons defasciculate and then steer into their muscle target regions. Here we describe the analysis of beaten path (beat), a gene required for the selective defasciculation of motor axons at these choice points. In beat mutant embryos, motor axons fail to defasciculate and bypass their targets. This phenotype is suppressed by mutations in FasII and conn, two genes encoding cell adhesion molecules expressed on motor axons, suggesting that beat provides an antiadhesive function. beat encodes a novel secreted protein that is expressed by motoneurons during outgrowth. Rescue and ectopic expression experiments support the model that Beat protein is secreted by motor axons where it functions to regulate their selective defasciculation at specific choice points.
BIOSIS ID	99334713
Zoological Record ID
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Secondary IDs
Language of Publication	English
Additional Languages of Abstract
ISBN
Parent Publication
Publication Type	Journal
Abbreviation	Cell
Title	Cell
Editors
Publication Year	1974-
ISBN/ISSN	0092-8674
Data from Reference
Aberrations (9)
	Df(2L)RM5 Df(2L)Sco^rv18 Df(2L)TE35D-19 In(2L)C163.41 In(2L)dpp^d36 In(2L)dpp^s22 In(2L)dpp^s22Ldpp^d36R In(2L)TE35B-210 In(2L)TE35B-210^LC163.41^R
Alleles (9)
	beat-Ia² beat-Ia³ beat-Ia^Scer\UAS.cFa Con^Fvex238 Fas2^e76 Fas2^e86 Fas2^e93 Scer\GAL4^elav-C155 Scer\GAL4^how-24B
Constructs (1)
	P{UAS-beat.F}
Genes (5)
	beat-Ia BicC Con Fas2 Scer\GAL4
Insertions (2)
	P{GawB}elav^C155 P{GawB}how^24B