Reference Report

Reference
Citation	Long, A.D., Mullaney, S.L., Mackay, T.F., Langley, C.H. (1996). Genetic interactions between naturally occurring alleles at quantitative trait loci and mutant alleles at candidate loci affecting bristle number in Drosophila melanogaster. Genetics 144(4): 1497--1510. (Export to RIS)
FlyBase ID	FBrf0091115
Publication Type	Research paper
PubMed ID	8978039
PubMed Abstract	Previously, we mapped quantitative trait loci (QTL) affecting response to short-term selection for abdominal bristle number to seven suggestive regions that contain loci involved in bristle development and/or that have adult bristle number mutant phenotypes, and are thus candidates for bristle number QTL in natural populations. To test the hypothesis that the factors contributing to selection response genetically interact with these candidate loci, high and low chromosomes from selection lines were crossed to chromosomes containing wild-type or mutant alleles at the candidate loci, and the numbers of bristles were recorded in trans heterozygotes. Quantitative failure to complement, detected as a significant selection line*cross effect by analysis of variance, can be interpreted as evidence for allelism or epistasis between the factors on selected chromosomes and the candidate loci. Mutations at some candidate loci (bb, emc, h, Dl, Hairless) showed strong interactions with selected chromosomes, whereas others interacted weakly (ASC, abd, Scr) or not at all (N, mab, E(spl)). These results support the hypothesis that some candidate loci, initially identified through mutations of large effect on bristle number, either harbor or are close members in the same genetic pathway as variants that contribute to standing variation in bristle number.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Genetics
Title	Genetics
Publication Year	1916-
ISBN/ISSN	0016-6731
Data from Reference
Aberrations (6)
	Df(1)88a15.1 Df(1)DEB Df(3L)h-i22 Df(3R)Espl1 Df(3R)Espl22 Df(3R)Scx2
Alleles (11)
	abd¹ Dl³ emc^H17 emc^P67 h¹ H¹ h⁴¹ mab¹ N^55e11 Scr¹⁷ Ybb¹
Genes (20)
	abd ac Antp bb bcd Dfd Dl E(spl)m8-HLH emc ftz h H mab N pb sc Scr y Ybb zen
Insertions (1)
	P{lArB}emc^P67