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Citation
Nakamura, A., Amikura, R., Mukai, M., Kobayashi, S., Lasko, P.F. (1996). Requirement for a noncoding RNA in Drosophila polar granules for germ cell establishment.  Science 274(5295): 2075--2079.
FlyBase ID
FBrf0091128
Publication Type
Research paper
Abstract

In Drosophila embryos, germ cell formation is induced by specialized cytoplasm at the posterior of the egg, the pole plasm. Pole plasm contains polar granules, organelles in which maternally produced molecules required for germ cell formation are assembled. An untranslatable RNA, called Polar granule component (Pgc), was identified and found to be localized in polar granules. Most pole cells in embryos produced by transgenic females expressing antisense Pgc RNA failed to complete migration and to populate the embryonic gonads, and females that developed from these embryos often had agametic ovaries. These results support an essential role for Pgc RNA in germline development.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Science
    Title
    Science
    Publication Year
    1895-
    ISBN/ISSN
    0036-8075
    Data From Reference
    Alleles (11)
    Genes (13)
    Transgenic Constructs (2)