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Citation
Parras, C., Garcia-Alonso, L.A., Rodriguez, I., Jimenez, F. (1996). Control of neural precursor specification by proneural proteins in the CNS of Drosophila.  EMBO J. 15(23): 6394--6399.
FlyBase ID
FBrf0091138
Publication Type
Research paper
Abstract

Formation of neural precursors in Drosophila is determined by proneural genes. The distinctive pattern of expression of some genes of the achaete-scute complex in the embryonic neuroectoderm has prompted the speculation that they could also function in the specification of neural precursor identity in the CNS. To test this hypothesis, we have analysed the capacity of different proneural proteins to promote the development of a particular CNS precursor, the MP2 precursor. Our results indicate that: (i) all known proneural proteins are similarly able to support the formation of a neural precursor at the position of MP2; (ii) different proneural proteins promote the expression of different characteristics of MP2; and (iii) a totally normal specification of the MP2 fate can only be attained by the proneural genes achaete or scute.

PubMed ID
PubMed Central ID
PMC452463 (PMC) (EuropePMC)
DOI
Associated Information
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    EMBO J.
    Title
    The EMBO Journal
    Publication Year
    1982-
    ISBN/ISSN
    0261-4189
    Data From Reference
    Aberrations (2)
    Alleles (10)
    Genes (13)
    Insertions (2)
    Experimental Tools (1)
    Transgenic Constructs (6)