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Simonova, O.B., Petruk, S.F., Korochkin, L.I. (1996). [Genetic analysis of combinations of the lawcp1 mutation with various alleles of AS-C genes in Drosophila.]  Genetika, Moscow 32(7): 949--955.
FlyBase ID
FBrf0091173
Publication Type
Research paper
Abstract

Phenotypic expression of mutations within the leg-aristal-wing complex (lawc) locus involves alteration of the number and location of macrochaetae. In Drosophila, development of macrochaetae depends on products of the two proneural genes, achaete (ac) and scute (sc), constituents of the approximately 90-kb ac-sc gene complex (AS-C). Untranscribed regions of AS-C involve enhancer-like cis-elements that are responsible for the local combination of some factors specifically determining expression of the ac-sc genes in larval imaginal discs of Drosophila. In the present work, the frequency of appearance of additional macrochaetae was tested to analyze phenotypic exhibition of the temperature-sensitive lawcp1 allele. This mutation was also genetically analyzed in combination with various AS-C alleles involving alterations of transcribed or cis-regulatory regions of this gene complex. A hypothesis that the lawc gene encodes a factor determining the specific expression of the ac-sc genes is discussed.

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    Language of Publication
    Russian
    Additional Languages of Abstract
    English
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Genetika, Moscow
    Title
    Genetika
    Publication Year
    1965-
    ISBN/ISSN
    0016-6758
    Data From Reference
    Alleles (1)
    Genes (3)