Reference Report

Reference
Citation	Zhang, N., Zhang, J., Purcell, K.J., Cheng, Y., Howard, K. (1997). The Drosophila protein Wunen repels migrating germ cells. Nature 385(6611): 64--67. (Export to RIS)
FlyBase ID	FBrf0091204
Publication Type	Research paper
PubMed ID	8985246
PubMed Abstract	In Drosophila, germ cells migrate in embryonic development from the lumen of the developing gut towards the overlying mesoderm, where they enter the gonads. The gene wunen is responsible for guiding the germ cells early in this process. Here we report that the protein Wunen has two properties that allow it to use repulsion to guide the germ cells. Wunen can transform a permissive cellular environment into a repulsive one, and is expressed in the gut in a pattern that guides germ cells towards the mesoderm. Wunen shows strong similarity to the enzyme type 2 phosphatidic acid phophatase (PAP2)4, suggesting that it is involved in lipid metabolism.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Nature
Title	Nature
Publication Year	1869-
ISBN/ISSN	0028-0836
Data from Reference
Alleles (11)
	l(2)03659⁰³⁶⁵⁹ l(2)k10201^+tNN l(2)k10201^+tNX l(2)k10201^k10201 Scer\GAL4^twi.PG w^+mC wun^+tNN wun^CE wun^k10201 wun^NX wun^Scer\UAS.cZa
Constructs (3)
	P{NN} P{NX} P{UAS-wun.Z}
Genes (5)
	l(2)03659 l(2)k10201 Scer\GAL4 w wun
Insertions (2)
	P{lacW}wun^k10201 P{PZ}l(2)03659⁰³⁶⁵⁹