Reference Report

Reference
Citation	Bhat, K.M., Schedl, P. (1997). Requirement for engrailed and invected genes reveals novel regulatory interactions between engrailed/invected, patched, gooseberry and wingless during Drosophila neurogenesis. Development 124(9): 1675--1688. (Export to RIS)
FlyBase ID	FBrf0093362
Publication Type	Research paper
PubMed ID	9165116
PubMed Abstract	During neurogenesis, the transmembrane protein Patched (Ptc) promotes a wingless (wg)-mediated specification of a neuronal precursor cell, NB4-2, by repressing gooseberry (gsb). In this study, novel interactions of these genes with engrailed (en) and invected (inv) during neurogenesis have been uncovered. While in row 4 cells Ptc represses gsb and wg, in row 5 cells en/inv relieve Ptc repression of gsb by a non-autonomous mechanism that does not involve hedgehog (hh). This differential regulation of gsb leads to the specification of NB5-3 and NB4-2 identities to two distinct neuroblasts. The uncoupling of the ptc-gsb regulatory circuit also enables gsb to promote Wg expression in row 5 cells. Our results suggest that the en/inv-->ptc-->gsb-->wg pathway uncovered here and the hh-->wg are distinct pathways that function to maintain wild-type level of Wg. Our results also indicate that Hh is not the only ligand for Ptc and similarly Ptc is not the only receptor for Hh.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Aberrations (3)
	Df(2R)en^E Df(2R)en-SFX31 Df(2R)gsb
Alleles (14)
	Ecol\lacZ^hkb-5953 en⁵⁴ en^E gsb^hs.PZ hh³ hh⁸ hh¹¹ hh^AC inv³⁰ inv^E ptc⁹ wg^hs.PN wg^l-8 wg^l-17
Constructs (2)
	P{hs-gsb-d.Z} P{HS-wg}
Genes (10)
	ac Ecol\lacZ en eve gsb hh inv ptc run wg
Insertions (1)
	P{lacZ-un4}hkb⁵⁹⁵³