A Database of Drosophila Genes & Genomes

FB2008_07, released August 8, 2008
 

Reference Report

Reference
Citation Boube, M., Benassayag, C., Seroude, L., Cribbs, D.L. (1997). Ras1-mediated modulation of Drosophila homeotic function in cell and segment identity.  Genetics 146(2): 619--628.
FlyBase ID FBrf0093373
Type of publication Research paper
Offprint Available Yes
External Crossreferences
PubMed ID 9178011
PubMed Abstract Mutations of the Drosophila homeotic proboscipedia gene (pb, the Hox-A2/B2 homologue) provoke dose-sensitive defects. These were used to search for dose-sensitive dominant modifiers of pb function. Two identified interacting genes were the proto-oncogene Ras1 and its functional antagonist Gap1, prominent intermediaries in known signal transduction pathways. Ras1+ is a positive modifier of pb activity both in normal and ectopic cell contexts, while the Ras1-antagonist Gap1 has an opposite effect. A general role for Ras1 in homeotic function is likely, since Ras1+ activity also modulates functions of the homeotic loci Sex combs reduced and Ultrabithorax. Our data suggest that the modulation occurs by a mechanism independent of transcriptional control of the homeotic loci themselves, or of the Ras1/Gap1 genes. Taken together our data support a role for Ras1-mediated cell signaling in the homeotic control of segmental differentiation.
Biosis 99595912
Zoological record
hide Associated Information
Comments
Text of personal communication
Associated files
hide Related Publications
hide Also Published As
hide Other Reference Information
Secondary IDs
Language of publication English
Additional language(s) of abstract
ISBN
Place of publication
hide Published In
Abbreviation Genetics
Title Genetics
Authors
Volume range 1-
Year range 1916-
Page range
Publisher
Place of publication Austin, TX, etc
Language of publication English
ISBN/ISSN 0016-6731
CODEN GENTAE
hide Data from Reference
hideAberrations (21)
hideAlleles (9)
hideConstructs (1)
hideGenes (7)
hideInsertions (1)