Reference Report

Reference
Citation	Eresh, S., Riese, J., Jackson, D.B., Bohmann, D., Bienz, M. (1997). A CREB-binding site as a target for decapentaplegic signalling during Drosophila endoderm induction. EMBO J. 16(8): 2014--2022. (Export to RIS)
FlyBase ID	FBrf0093434
Publication Type	Research paper
PubMed ID	9155027
PubMed Abstract	Decapentaplegic (Dpp) is an extracellular signal of the transforming growth factor-beta family with multiple functions during Drosophila development. For example, it plays a key role in the embryo during endoderm induction. During this process, Dpp stimulates transcription of the homeotic genes Ultrabithorax in the visceral mesoderm and labial in the subjacent endoderm. Here, we show that a cAMP response element (CRE) from an Ultrabithorax enhancer mediates Dpp-responsive transcription in the embryonic midgut, and that endoderm expression from a labial enhancer depends on multiple CREs. Furthermore, the Drosophila CRE-binding protein dCREB-B binds to the Ultrabithorax CRE, and ubiquitous expression of a dominant-negative form of dCREB-B suppresses CRE-mediated reporter gene expression and reduces labial expression in the endoderm. Therefore, a CREB protein may act as a nuclear target, or as a partner of a nuclear target, for Dpp signalling in the embryonic midgut.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	EMBO J.
Title	The EMBO Journal
Publication Year	1982-
ISBN/ISSN	0261-4189
Data from Reference
Alleles (24)
	CrebB^a.Scer\UAS CrebB^B.Scer\UAS CrebB^Cbz.Scer\UAS dpp^s4 dpp^Scer\UAS.cSa Ecol\lacZ^lab.255C Ecol\lacZ^lab.550C Ecol\lacZ^lab.HZ255 Ecol\lacZ^lab.HZ550 Ecol\lacZ^Ubx.4CRE Ecol\lacZ^Ubx.4CRE-BC Ecol\lacZ^Ubx.4CRE-FL Ecol\lacZ^Ubx.5CRE Ecol\lacZ^Ubx.B5 Ecol\lacZ^Ubx.BC Ecol\lacZ^Ubx.Bhz Ecol\lacZ^Ubx.L-CRE Jra^Jbz.Scer\UAS Jra^Scer\UAS.cEa kay^Fbz.Scer\UAS kay^Scer\UAS.cEa Scer\GAL4^how-24B Scer\GAL4^hs.PB wg^hs.PN
Constructs (22)
	P{4CRE} P{4CRE-BC} P{4CRE-FL} P{5CRE} P{255C} P{550C} P{B5} P{BC} P{Bhz} P{Cbz} P{dCREB-2a-UAS} P{dCREB-B-UAS} P{GAL4-Hsp70.PB} P{HS-wg} P{HZ255} P{HZ550} P{Jbz} P{L-CRE} P{UAS-dpp.S} P{UAS-Fra.Fbz} P{UAS-Fra} P{UAS-Jra}
Genes (10)
	CrebA CrebB dpp Ecol\lacZ Jra kay lab Scer\GAL4 Ubx wg
Insertions (1)
	P{GawB}how^24B
Sequence features (4)
	Ubx_4CRE Ubx_B Ubx-protein_bind-22 Ubx-protein_bind-26