Reference Report

Reference
Citation	Giebel, B., Stuttem, I., Hinz, U., Campos-Ortega, J.A. (1997). Lethal of scute requires overexpression of daughterless to elicit ectopic neuronal development during embryogenesis in Drosophila. Mech. Dev. 63(1): 75--87. (Export to RIS)
FlyBase ID	FBrf0093461
Publication Type	Research paper
PubMed ID	9178258
PubMed Abstract	Classical genetics indicates that the achaete-scute gene complex (AS-C) of Drosophila promotes development of neural progenitor cells. To further analyze the function of proneural genes, we have studied the effects of Gal4-mediated expression of lethal of scute, a member of the AS-C, during embryogenesis. Expression of lethal of scute forces progenitor cells of larval internal sensory organs, which are normally committed to this fate independently of the activity of the AS-C, to take on features of external sensory organs. Supernumerary neural cells can be induced ectopically only if daughterless is overexpressed, either alone or together with lethal of scute: cells of the amnioserosa and the hindgut then express neuronal markers. Furthermore, cells of the proctodeal anlage, which normally lack neural competence, acquire the ability to develop as neuroblasts following transplantation into the neuroectoderm. We show here that activated Notch prevents the cells of the neuroectoderm from forming extra neural tissue when they express an excess of proneural proteins. Under the present conditions, lateral inhibition is thus dominant over the activity of proneural genes.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Mech. Dev.
Title	Mechanisms of Development
Publication Year	1990-
ISBN/ISSN	0925-4773
Data from Reference
Aberrations (5)
	Df(1)260-1 Df(3R)Dl-FX3 Df(3R)gro^b32.2 In(1)FM7 In(2LR)O
Alleles (12)
	da¹⁰ da^IIP106 da^KE38 da^Scer\UAS.cGa Dl::N^{ΔECN.Scer\UAS} l(1)sc^Scer\UAS.cHa N^55e11 N^{int.SH.Scer\UAS} Scer\GAL4^da.G32 Scer\GAL4^Kr.PM Scer\GAL4^rho.PL Scer\GAL4^sca-537.4
Balancers (2)
	CyO-vKa FM7c-vHa
Constructs (7)
	P{GAL4-da.G32} P{GAL4-Kr.C} P{GAL4-ve.L} P{UAS-da.G} P{UAS-Dl::N.ΔECN} P{UAS-l(1)sc.LSC} P{UAS-N.intra.SH}
Genes (14)
	ac ase ct Cyp4g1 da Dl Dl::N l(1)sc N sc Scer\GAL4 scrt sna Su(H)
Insertions (1)
	P{GawB}sca^537.4