Reference Report

Reference
Citation	Strutt, D.I., Weber, U., Mlodzik, M. (1997). The role of RhoA in tissue polarity and Frizzled signalling. Nature 387(6630): 292--295. (Export to RIS)
FlyBase ID	FBrf0093742
Publication Type	Research paper
External Crossreferences
PubMed ID	9153394
PubMed Abstract	The tissue polarity genes of Drosophila are required for correct establishment of planar polarity in epidermal structures, which in the eye is shown in the mirror-image symmetric arrangement of ommatidia relative to the dorsoventral midline. Mutations in the genes frizzled (fz), dishevelled (dsh) and prickle-spiny-legs (pk-sple) result in the loss of this mirror-image symmetry. fz encodes a serpentine receptor-like transmembrane protein required for reception and transmission of a polarity signal. Little else is known of the signalling pathway(s) involved other than that Dsh acts downstream of Fz. We have identified mutations in the Drosophila homologue of RhoA p21 GTPase, and by analysis of their phenotype show that RhoA is required for the generation of tissue polarity. Genetic interactions indicate a role for RhoA in signalling mediated by Fz and Dsh, and furthermore suggest that JNK/SAPK-like kinases are involved. These data are consistent with a Fz/RhoA signalling cascade analogous to the yeast pheromone signalling pathway and that proposed for activation of the serum response factor (SRF) in vertebrate cells.
BIOSIS ID	99565202
Zoological Record ID
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Associated Information
Comments
Text of Personal Communication
Associated Files
Other Information
Secondary IDs	FBrf0096384
Language of Publication	English
Additional Languages of Abstract
ISBN
Parent Publication
Publication Type	Journal
Abbreviation	Nature
Title	Nature
Editors
Publication Year	1869-
ISBN/ISSN	0028-0836
Data from Reference
Alleles (22)
	bsk¹ bsk² dsh³ dsh^Scer\UAS.cNa Ecol\lacZ^svp-3 fz¹ fz^Scer\UAS.cAa nmo^E33 pk^pk-sple-13 Rho1^72BH Rho1^72F Rho1^72M1 Rho1^72O Rho1^72R Rho1^k07236 Rho1^k07903 Rho1^N19.Scer\UAS rl¹⁰ Scer\GAL4^dpp.blk1 Scer\GAL4^hs.2sev w^+mC wg^l-17
Constructs (5)
	P{GAL4-dpp.blk1} P{GAL4-Hsp70.sev} P{UAS-dsh.N} P{UAS-fz.A} P{UAS-Rho1.N19}
Genes (12)
	bsk dsh Ecol\lacZ elav fz nmo pk Rho1 rl Scer\GAL4 w wg
Insertions (3)
	P{HZ}svp³ P{lacW}Rho1^k07236 P{lacW}Rho1^k07903