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Reference
Citation	Thomas, U., Phannavong, B., Muller, B., Garner, C.C., Gundelfinger, E.D. (1997). Functional expression of rat synapse-associated proteins SAP97 and SAP102 in Drosophila dlg-1 mutants: effects on tumor suppression and synaptic bouton structure. Mech. Dev. 62(2): 161--174.
FlyBase ID	FBrf0093753
Type of publication	Research paper
Offprint Available	Yes
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PubMed ID	9152008
PubMed Abstract	The synapse-associated proteins SAP97 and SAP102 are mammalian proteins that are structurally related to the Drosophila tumor suppressor protein DlgA. Previous analyses revealed that DlgA is essential for the integrity of epithelia and neuromuscular synapses. Here we show that synaptic bouton structure is severely affected in mutant larvae carrying the dlg-1(XI-2) allele. We have tested SAP97 and SAP102 for functional homology to DlgA by heterologous expression in Drosophila. Both SAP97 and SAP102 can suppress tumor formation in dlg-1 mutant flies and mimic DlgA at larval neuromuscular junctions. Neuronal expression of SAP97 or SAP102 is required for morphological restoration of synaptic boutons, indicating that presynaptic DlgA function is essential for establishing structurally intact motor nerve terminals at larval neuromuscular junctions.
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Language of publication	English
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Abbreviation	Mech. Dev.
Title	Mechanisms of Development
Authors
Volume range	33-
Year range	1990-
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Publisher
Place of publication	Shannon
Language of publication	English
ISBN/ISSN	0925-4773
CODEN	MEDVE6
Data from Reference
Aberrations (1)
	Df(3L)H99
Alleles (10)
	Ecol\lacZ^Scer\UAS.cBa Rnor\SAP102^Scer\UAS.cTa Rnor\SAP97^Scer\UAS.cTa Scer\GAL4^da.G32 Scer\GAL4^elav.PLu Scer\GAL4^ptc-559.1 dlg1² dlg1⁵ dlg1⁷ w^+mC
Constructs (4)
	P{GAL4-da.G32} P{GAL4-elav.L} P{UAS-Rat\SAP102.T} P{UAS-Rat\SAP97.T}
Genes (8)
	Ecol\lacZ Rnor\SAP102 Rnor\SAP97 Scer\GAL4 crb dlg1 syt w
Insertions (1)
	P{GawB}ptc^559.1