Reference Report

Reference
Citation	Alphey, L., Parker, L., Hawcroft, G., Guo, Y., Kaiser, K., Morgan, G. (1997). KLP38B: A mitotic kinesin-related protein that binds PP1. J. Cell Biol. 138(2): 395--409. (Export to RIS)
FlyBase ID	FBrf0093937
Publication Type	Research paper
PubMed ID	9230081
PubMed Abstract	We have identified a new member of the kinesin superfamily in Drosophila, KLP38B (kinesin-like protein at 38B). KLP38B was isolated through its two-hybrid interaction with the catalytic subunit of type 1 serine/threonine phosphoprotein phosphatase (PP1). We demonstrate that recombinant KLP38B and PP1 associate in vitro. This is the first demonstration of direct binding of a kinesin-related protein to a regulatory enzyme. Though most closely related to the Unc-104 subfamily of kinesin-related proteins, KLP38B is expressed only in proliferating cells. KLP38B mutants show cell proliferation defects in many tissues. KLP38B is required for normal chromatin condensation as embryos from KLP38B mutant mothers have undercondensed chromatin at metaphase and anaphase. This is the first time that a kinesin-related protein has been shown to have such a role. Incomplete lethality of a strong KLP38B allele suggests partial redundancy with one or more additional kinesin-related proteins.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	J. Cell Biol.
Title	Journal of Cell Biology
Publication Year	1966-
ISBN/ISSN	0021-9525
Data from Reference
Aberrations (4)
	Df(2L)barr^k04805 Df(2L)barr^k04912 Df(2L)pr-A20 Df(2L)TW9
Alleles (10)
	neb^24-O neb^93-E neb^Hsp26.PA neb^k00802 neb^k03903 neb^k04805 neb^k04912 neb^k04914 neb^k05702 w^+mW.hs
Constructs (1)
	P{Hsp26-Klp38B}
Genes (4)
	barr neb Pp1-87B w
Insertions (7)
	P{lacW}barr^k04805 P{lacW}neb^24-O P{lacW}neb^93-E P{lacW}neb^k00802 P{lacW}neb^k03903 P{lacW}neb^k04914 P{lacW}neb^k05702