Reference Report

Reference
Citation	Bhadra, U., Pal-Bhadra, M., Birchler, J.A. (1997). A trans-acting modifier causing extensive overexpression of genes in Drosophila melanogaster. Mol. Gen. Genet. 254(6): 621--634. (Export to RIS)
FlyBase ID	FBrf0094159
Publication Type	Research paper
PubMed ID	9202378
PubMed Abstract	A modified P element-induced mutation at cytological position 47A11-12 on chromosome 2 of Drosophila melanogaster inversely alters the expression of several genes examined. In addition, the effect is nearly exponential in some developmental stages for five of the eleven genes tested (white, brown, scarlet, rudimentary and vermilion). Interestingly, the exponential overexpression of the transcripts leads to a sexually dimorphic effect, with female levels being greater. The white allele specificity analysis and the lack of response of an Alcohol dehydrogenase promoter-white reporter fusion construct suggest that the 5' regulatory sequences of white are required for the response. Because the cases of extreme overexpression are more prominent in females than males, the locus is termed Ultra female overexpression (Ufo). Ufo revertants have no discernible effect on the transcript levels, indicating that the mutation is responsible for the modulation of the tested genes. Regulatory genes such as Ufo may contribute to the wide fluctuations in gene expression between tissues and stages of development.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Mol. Gen. Genet.
Title	Molecular and General Genetics
Publication Year	1967-2001
ISBN/ISSN	0026-8925
Data from Reference
Aberrations (4)
	Df(2R)D203 Dp(1;1)w⁺61e19 Dp(2;Y)D203 Tp(2;Y)D203
Alleles (42)
	Ufo¹ Ufo^R w^-17 w^-113 w^+mC w^+mF w^a2 w^a3 w^a4 w^a59k1 w^a w^aM w^apl w^aR84h w^bf2 w^bf w^BgB+173 w^bl w^Bwx w^c w^cf w^co w^col w^e w^E w^h wⁱ w^IR1 w^IR2 w^IR3 w^IR4 w^IR5 w^IR6 w^ric w^sat w^sp1 w^sp2 w^sp3 w^sp4 w^sp55 w^sp81d w^Z4-17
Constructs (6)
	P{(-113)miniW} P{BgB-(+173)miniW} P{CaSpeR-4} P{wE} P{wF} P{Z4(-17)miniW}
Genes (12)
	Adh bw east Pgd r Sos st Ufo v w z βTub56D
Insertions (20)
	3S18{}w^a4 blood{}w^bl copia{3'LTR}w^a59k1 copia{}w^a Doc{}w¹ I{407}w^IR3 I{}w^aR84h I{}w^IR1 I{}w^IR4 I{}w^IR5 I{}w^IR6 mdg3{}w^sp55 P{}w^apl P{PZ}Ufo¹ pogo{}w^e roo{}w^bf2 roo{}w^bf roo{}w^h roo{}w^ric roo{}w^sp1
Natural transposons (1)
	copia