Reference Report

Reference
Citation	Eberl, D.F., Lorenz, L.J., Melnick, M.B., Sood, V., Lasko, P., Perrimon, N. (1997). A new enhancer of position-effect variegation in Drosophila melanogaster encodes a putative RNA helicase that binds chromosomes and is regulated by the cell cycle. Genetics 146(3): 951--963. (Export to RIS)
FlyBase ID	FBrf0094604
Publication Type	Research paper
PubMed ID	9215899
PubMed Abstract	In Drosophila melanogaster, position-effect variegation of the white gene has been a useful phenomenon by which to study chromosome structure and the genes that modify it. We have identified a new enhancer of variegation locus, Dmrnahel (hel). Deletion of mutation of hel enhances white variegation, and this can be reversed by a transformed copy of hel+. In the presence of two endogenous copies, the transformed hel+ behaves as a suppressor of variegation. hel is an essential gene and functions both maternally and zygotically. The HEL protein is similar to known RNA helicases, but contains an unusual variant (DECD) of the DEAD motif common to these proteins. Potential HEL homologues have been found in mammals, yeast and worms. HEL protein associates with salivary gland chromosomes and locates to nuclei of embryos and ovaries, but disappears in mitotic domains of embryos as chromosomes condense. We propose that the HEL protein promotes an open chromatin structure that favors transcription during development by regulating the spread of heterochromatin, and that HEL is regulated by, and may have a role in, the mitotic cell cycle during embryogenesis.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Genetics
Title	Genetics
Publication Year	1916-
ISBN/ISSN	0016-6731
Data from Reference
Aberrations (4)
	Df(2L)cl-h1 Df(2L)cl-h2 Df(2L)cl-h4 In(1)w^m4
Alleles (19)
	Hel25E³ Hel25E^+t4.5 l(2)25Ea² l(2)25Ed⁶ l(2)25Ed⁷ l(2)25Ee⁵ l(2)25Ef⁴ l(2)25Ef⁵ Lam^a7 Lam^sz9 Lam^sz18 nompC¹ nompC³ nompC⁴ nompC⁵ vri¹ vri² w^+mC y^+mDint2
Constructs (2)
	P{Hel25E^+t4.5.w} P{Hel25E^+t4.5.y}
Genes (15)
	cl Hel25E l(2)25Ea l(2)25Ed l(2)25Ee l(2)25Ef Lam nompC vri w y βTub56D βTub60D βTub85D βTub97EF