Reference Report

Reference
Citation	George, H., Terracol, R. (1997). The vrille gene of Drosophila is a maternal enhancer of decapentaplegic and encodes a new member of the bZIP family of transcription factors. Genetics 146(4): 1345--1363. (Export to RIS)
FlyBase ID	FBrf0094777
Publication Type	Research paper
PubMed ID	9258679
PubMed Abstract	We report here the genetical and molecular characterization of a new Drosophila zygotic lethal locus, vrille (vri). Vri alleles act not only as dominant maternal enhancers of embryonic dorsoventral patterning defects caused by easter and decapentaplegic (dpp) mutations, but also as dominant zygotic enhancers of dpp alleles for phenotypes in wing. The vri gene encodes a new member of the bZIP family of transcription factors closely related to gene 9 of Xenopus laevis, induced by thyroid hormone during the tadpole tail resorption program, and NF-IL3A, a human T cell transcription factor that transactivates the interleukin-3 promoter. NF-IL3A shares 93% similarity and 60% identity with Vri for a stretch of 68 amino acids that includes the bZIP domain. Although all the alleles tested behave like antimorphs, the dominant enhancement is also seen with a nonsense mutation allele that prevents translation of the bZIP domain. Because of the strong domainant enhancement of dpp phenotypes by vri alleles in both embryo and wing, and also the similarity between the wing vein phenotypes caused by the vri and shortvein dpp alleles, we postulate that vri interacts either directly or indirectly with certain components of the dpp (a TGF beta homologue) signal transduction pathway.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Genetics
Title	Genetics
Publication Year	1916-
ISBN/ISSN	0016-6731
Data from Reference
Aberrations (9)
	Df(2L)cl1 Df(2L)cl7 Df(2L)cl-h2 Df(2L)tkv2 Df(2L)tkv3 Dp(2;1)B19 In(2L)tkv^Sz-1 Tp(2;1)B19 Tp(2;3)tkv
Alleles (43)
	cype⁰³⁷⁷¹ dpp^d6 dpp^hr4 dpp^hr27 ea^161.13 Ecol\lacZ^cype-03771 Ecol\lacZ^tkv-04415 Ecol\lacZ^vri-k03801 Ecol\lacZ^vri-k05901 Ecol\lacZ^vri-k09602 Ecol\lacZ^vri-k09713 Ecol\lacZ^vri-k11805 Mad⁶ nompC¹ nompC² nompC³ nompC⁴ nompC⁵ put¹³⁵ shn¹ tkv³ tkv⁰⁴⁴¹⁵ tkv^k16713 tkv^Ubi-p63E.PB vri¹ vri² vri³ vri^5R4.11 vri^5R5.7 vri^5R5.24 vri^5R7.2 vri^5R8.4 vri^hs.PG vri^K17 vri^k03801 vri^k05901 vri^k09602 vri^k09713 vri^k11805 vri^SK10 vri^X5 w^+mC w^+mW.hs
Constructs (5)
	P{hs-vri.G} P{Ubi-tkv-1} P{vri.K17} P{vri.SK10} P{vri.X5}
Genes (16)
	anon-25Da anon-25Db anon-25Dc Bsg25D cype dpp ea Ecol\lacZ Mad nompC put shn tkv vri w zen
Insertions (8)
	P{lacW}tkv^k16713 P{lacW}vri^k03801 P{lacW}vri^k05901 P{lacW}vri^k09602 P{lacW}vri^k09713 P{lacW}vri^k11805 P{PZ}cype⁰³⁷⁷¹ P{PZ}tkv⁰⁴⁴¹⁵