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Citation	Giesen, K., Hummel, T., Stollewerk, A., Harrison, S., Travers, A., Klambt, C. (1997). Glial development in the Drosophila CNS requires concomitant activation of glial and repression of neuronal differentiation genes. Development 124(12): 2307--2316.
FlyBase ID	FBrf0094782
Type of publication	Research paper
Offprint Available	Yes
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PubMed ID	9199357
PubMed Abstract	Two classes of glial cells are found in the embryonic Drosophila CNS, midline glial cells and lateral glial cells. Midline glial development is triggered by EGF-receptor signalling, whereas lateral glial development is controlled by the gcm gene. Subsequent glial cell differentiation depends partly on the pointed gene. Here we describe a novel component required for all CNS glia development. The tramtrack gene encodes two zinc-finger proteins, one of which, ttkp69, is expressed in all non-neuronal CNS cells. We show that ttkp69 is downstream of gcm and can repress neuronal differentiation. Double mutant analysis and coexpression experiments indicate that glial cell differentiation may depend on a dual process, requiring the activation of glial differentiation by pointed and the concomitant repression of neuronal development by tramtrack.
Biosis	99662190
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Language of publication	English
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Abbreviation	Development
Title	Development
Authors
Volume range	99-
Year range	1987-
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Place of publication	Cambridge
Language of publication	English
ISBN/ISSN	0950-1991
CODEN	DEVPED
Data from Reference
Aberrations (1)
	Df(3R)awd-KRB
Alleles (19)
	Ecol\lacZ^AA142 Ecol\lacZ^gcm-rA87 Ecol\lacZ^rI50 Ecol\lacZ^ttk-10556 Scer\GAL4^Kr.PM Scer\GAL4^sca-537.4 Scer\GAL4^sli.PS pnt^P1.Scer\UAS pnt^Δ88 ttk¹⁰⁵⁵⁶ ttk¹ ttk^1e11 ttk⁵³⁴⁶ ttk^B330 ttk^D2-50 ttk^osn ttk^p69.Scer\UAS ttk^p88.Scer\UAS ttk^rM730
Constructs (5)
	P{GAL4-Kr.C} P{GAL4-sli.S} P{UAS-pnt.P1} P{UAS-ttk.p69} P{UAS-ttk.p88}
Genes (11)
	Ecol\lacZ Fas2 Scer\GAL4 elav gcm pnt pros repo sna trh ttk
Insertions (9)
	P{GawB}sca^537.4 P{PZ}gcm^rA87 P{PZ}ttk¹⁰⁵⁵⁶ P{PZ}ttk¹ P{PZ}ttk⁵³⁴⁶ P{lacW}ttk^osn P{lacZ-un1}rI50 P{lacZ}ttk^rM730 P{lwB}AA142