Reference Report

Reference
Citation	Giesen, K., Hummel, T., Stollewerk, A., Harrison, S., Travers, A., Klambt, C. (1997). Glial development in the Drosophila CNS requires concomitant activation of glial and repression of neuronal differentiation genes. Development 124(12): 2307--2316. (Export to RIS)
FlyBase ID	FBrf0094782
Publication Type	Research paper
PubMed ID	9199357
PubMed Abstract	Two classes of glial cells are found in the embryonic Drosophila CNS, midline glial cells and lateral glial cells. Midline glial development is triggered by EGF-receptor signalling, whereas lateral glial development is controlled by the gcm gene. Subsequent glial cell differentiation depends partly on the pointed gene. Here we describe a novel component required for all CNS glia development. The tramtrack gene encodes two zinc-finger proteins, one of which, ttkp69, is expressed in all non-neuronal CNS cells. We show that ttkp69 is downstream of gcm and can repress neuronal differentiation. Double mutant analysis and coexpression experiments indicate that glial cell differentiation may depend on a dual process, requiring the activation of glial differentiation by pointed and the concomitant repression of neuronal development by tramtrack.
DOI
Related Publication(s)
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
Language of Publication	English
Additional Languages of Abstract
Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Aberrations (1)
	Df(3R)awd-KRB
Alleles (19)
	Ecol\lacZ^AA142 Ecol\lacZ^gcm-rA87 Ecol\lacZ^rI50 Ecol\lacZ^ttk-10556 pnt^P1.Scer\UAS pnt^Δ88 Scer\GAL4^Kr.PM Scer\GAL4^sca-537.4 Scer\GAL4^sli.PS ttk¹ ttk^1e11 ttk⁵³⁴⁶ ttk¹⁰⁵⁵⁶ ttk^B330 ttk^D2-50 ttk^osn ttk^p69.Scer\UAS ttk^p88.Scer\UAS ttk^rM730
Constructs (5)
	P{GAL4-Kr.C} P{GAL4-sli.S} P{UAS-pnt.P1} P{UAS-ttk.p69} P{UAS-ttk.p88}
Genes (11)
	Ecol\lacZ elav Fas2 gcm pnt pros repo Scer\GAL4 sna trh ttk
Insertions (9)
	P{GawB}sca^537.4 P{lacW}ttk^osn P{lacZ-un1}rI50 P{lwB}AA142 P{PZ}gcm^rA87 P{PZ}ttk¹ P{PZ}ttk⁵³⁴⁶ P{PZ}ttk¹⁰⁵⁵⁶ P{PZ}ttk^rM730