Reference Report

Reference
Citation	Glise, B., Noselli, S. (1997). Coupling of Jun amino-terminal kinase and Decapentaplegic signaling pathways in Drosophila morphogenesis. Genes Dev. 11(13): 1738--1747. (Export to RIS)
FlyBase ID	FBrf0094789
Publication Type	Research paper
PubMed ID	9224722
PubMed Abstract	Dorsal closure in Drosophila embryos involves the migration of two lateral epithelia toward the dorsal midline to establish the dorsal ectoderm. Previous work showed that this morphogenetic movement depends on the activities of a Jun amino (N)-terminal kinase kinase (JNKK) encoded by the hemipterous (hep) gene, and of a JNK encoded by basket. Hep is required for cell determination in the leading edge of migrating epithelia, by controlling specific expression of the puckered (puc) gene in these cells. During dorsal closure, decapentaplegic (dpp), a member of the transforming growth factor-beta (TGF-beta) superfamily, is expressed in the row of cells making up the leading edge of the epithelia. Here, we show that the small GTPases Dcdc42, Drac1, and the Hep JNKK control dpp expression in this migratory process. Appropriate dpp and puc expression in the leading edge also depends on the inhibitory function of the puc gene. Further, our data suggest that the leading edge is the source of a JNK autocrine signal, and exclude a role of Dpp as such a ligand. Dorsal closure couples JNK and dpp signaling pathways, a situation that may be conserved in vertebrate development.
DOI
Related Publication(s)
Review	Monitor. Anonymous, 1997, Trends Genet. 13(10): 392 [FBrf0098946] Connecting up the pathways in Drosophila development. Riesgo-Escovar et al., 1997, Trends Cell Biol. 7(11): 421--422 [FBrf0099820]
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Genes Dev.
Title	Genes & Development
Publication Year	1987-
ISBN/ISSN	0890-9369
Data from Reference
Alleles (14)
	Cdc42^V12.Scer\UAS dpp^Scer\UAS.cNa Ecol\lacZ^puc-E69 hep¹ hep^r75 phl^{Scer\UAS.F179} puc¹ Rac1^V12.Scer\UAS Ras64B^{Val14.Scer\UAS} Scer\GAL4^69B Scer\GAL4^en-e16E Scer\GAL4^LE Scer\GAL4^wg.PM tkv^{Q253D.Scer\UAS.cNb}
Constructs (7)
	P{GAL4-wg.M} P{UAS(-FRT)dpp.N} P{UAS-Cdc42.V12} P{UAS-phl.gof} P{UAS-Rac1.V12} P{UAS-Ras64B.V14} P{UAS-tkv.Q253D.Nb}
Genes (11)
	bsk Cdc42 dpp Ecol\lacZ hep phl puc Rac1 Ras64B Scer\GAL4 tkv
Insertions (4)
	P{A92}puc^E69 P{en2.4-GAL4}e16E P{GAL4}LE P{GawB}69B