Reference Report

Reference
Citation	Kockel, L., Zeitlinger, J., Staszewski, L.M., Mlodzik, M., Bohmann, D. (1997). Jun in Drosophila development: redundant and nonredundant functions and regulation by two MAPK signal transduction pathways. Genes Dev. 11(13): 1748--1758. (Export to RIS)
FlyBase ID	FBrf0095439
Publication Type	Research paper
PubMed ID	9224723
PubMed Abstract	Drosophila Jun is shown to be involved in different signal transduction pathways and developmental decisions. Dorsal closure, a morphogenetic process occurring during Drosophila embryogenesis, is regulated by Hemipterous (Hep) and Basket (Bsk), homologs of JNKK and JNK, respectively. Embryos lacking Jun activity exhibit a dorsal closure phenotype, very similar to that of bsk and hep mutants, indicating that Jun is a target of Hep/Bsk signaling. In eye and wing development Jun participates in a separate signaling pathway that is comprised of Ras, Raf, and the ERK-type kinase Rolled. In contrast to the strict requirement for Jun in dorsal closure, its role in the eye is redundant but can be uncovered by mutations in other signaling components. The redundant function of Jun in eye development may contribute to the precision of photoreceptor differentiation and ommatidial assembly.
DOI
Related Publication(s)
Review	Monitor. Anonymous, 1997, Trends Genet. 13(10): 392 [FBrf0098946] Connecting up the pathways in Drosophila development. Riesgo-Escovar et al., 1997, Trends Cell Biol. 7(11): 421--422 [FBrf0099820]
Erratum	Jun in Drosophila development: redundant and nonredundant functions and regulation by two MAPK signal transduction pathways. Kockel et al., 1998, Genes Dev. 12(3): 447 [FBrf0100784]
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
Language of Publication	English
Additional Languages of Abstract
Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Genes Dev.
Title	Genes & Development
Publication Year	1987-
ISBN/ISSN	0890-9369
Data from Reference
Aberrations (2)
	Df(2R)E73 In(2LR)O
Alleles (19)
	14-3-3ζ⁰⁷¹⁰³ 14-3-3ζ^E73 bsk² Egfr^E3 Jra¹ Jra^Ala.hs.sev Jra^Asp.hs.sev Jra^IA109 Jra^Jbz.Scer\UAS Ras85D^V12.Scer\UAS rl^10a rl^Sem Scer\GAL4^69B Scer\GAL4^C-765 Scer\GAL4^hs.PB sev⁶ sev^{S11.hs.T:Hsap\MYC} sev^{S11.T:Hsap\MYC} Sos^JC2
Balancers (1)
	CyO-P{en1}wg^en11
Constructs (6)
	P{GAL4-Hsp70.PB} P{Jbz} P{sE-jun^Ala} P{sE-jun^Asp} P{sev5} P{UAS-Ras85D.V12}
Genes (11)
	14-3-3ζ bsk cora Egfr Jra Ras85D rl Scer\GAL4 sev Sos T:Hsap\MYC
Insertions (3)
	P{GawB}69B P{GawB}C-765 P{PZ}14-3-3ζ⁰⁷¹⁰³