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Citation
Osborne, K.A., Robichon, A., Burgess, E., Butland, S., Shaw, R.A., Coulthard, A., Pereira, H.S., Greenspan, R.J., Sokolowski, M.B. (1997). Natural behavior polymorphism due to a cGMP-dependent protein kinase of Drosophila.  Science 277(5327): 834--836.
FlyBase ID
FBrf0096020
Publication Type
Research paper
Abstract

Naturally occuring polymorphisms in behavior are difficult to map genetically and thus are refractory to molecular characterization. An exception is the foraging gene (for), a gene that has two naturally occurring variants in Drosophila melanogaster food-search behavior: rover and sitter. Molecular mapping placed for mutations in the dg2 gene, which encodes a cyclic guanosine monophosphate (cGMP)-dependent protein kinase (PKG). Rovers had higher PKG activity than sitters, and transgenic sitters expressing a dg2 complementary DNA from rover showed transformation of behavior to rover. Thus, PKG levels affected food-search behavior, and natural variation in PKG activity accounted for a behavioral polymorphism.

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Personal communication to FlyBase

189Y update.
Sokolowski, 2006.8.25, 189Y update. [FBrf0198702]

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Science
    Title
    Science
    Publication Year
    1895-
    ISBN/ISSN
    0036-8075
    Data From Reference
    Alleles (8)
    Genes (4)
    Insertions (1)
    Transgenic Constructs (1)
    Transcripts (1)