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Citation
Panin, V.M., Papayannopoulos, V., Wilson, R., Irvine, K.D. (1997). Fringe modulates Notch-ligand interactions.  Nature 387(6636): 908--912.
FlyBase ID
FBrf0096031
Publication Type
Research paper
Abstract

The Notch family of transmembrane receptor proteins mediate developmental cell-fate decisions, and mutations in mammalian Notch genes have been implicated in leukaemia, breast cancer, stroke and dementia. During wing development in Drosophila, the Notch receptor is activated along the border between dorsal and ventral cells, leading to the specification of specialized cells that express Wingless (Wg) and organize wing growth and patterning. Three genes, fringe (fng), Serrate (Ser) and Delta (Dl), are involved in the cellular interactions leading to Notch activation. Ser and Dl encode transmembrane ligands for Notch, whereas fng encodes a pioneer protein. We have investigated the relationship between these genes by a combination of expression and coexpression studies in the Drosophila wing. We found that Ser and Dl maintain each other's expression by a positive feedback loop. fng is expressed specifically by dorsal cells and functions to position and restrict this feedback loop to the developing dorsal-ventral boundary. This is achieved by fng through a cell-autonomous mechanism that inhibits a cell's ability to respond to Serrate protein and potentiates its ability to respond to Delta protein.

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Related Publication(s)
Review

Notch signaling - beyond the FRINGE.
Anonymous, 1997, Trends Genet. 13(9): 352 [FBrf0098933]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Nature
    Title
    Nature
    Publication Year
    1869-
    ISBN/ISSN
    0028-0836
    Data From Reference
    Alleles (10)
    Gene Groups (3)
    Genes (8)
    Insertions (1)
    Experimental Tools (2)
    Transgenic Constructs (6)