Reference Report

Reference
Citation	Scholz, H., Sadlowski, E., Klaes, A., Klambt, C. (1997). Control of midline glia development in the embryonic Drosophila CNS. Mech. Dev. 64(1-2): 137--151. (Export to RIS)
FlyBase ID	FBrf0096245
Publication Type	Erratum
PubMed ID	9232604
PubMed Abstract	The midline glial cells are required for correct formation of the axonal pattern in the embryonic ventral nerve cord of Drosophila. Initially, six midline cells form an equivalence group with the capacity to develop as glial cells. By the end of embryonic development three to four cells are singled out as midline glial cells. Midline glia development occurs in two steps, both of which depend on the activation of the Drosophila EGF-receptor homolog and subsequent ras1/raf-mediated signal transduction. Nuclear targets of this signalling cascade are the ETS domain transcription factors pointedP2 and yan. In the midline glia pointedP2 in turn activates the transcription of argos, which encodes a diffusible negative regulator of EGF-receptor signalling.
DOI
Related Publication(s)
Research paper	Control of midline glia development in the embryonic Drosophila CNS. Scholz et al., 1997, Mech. Dev. 62(1): 79--91 [FBrf0093209]
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Secondary IDs
Language of Publication	English
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Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Mech. Dev.
Title	Mechanisms of Development
Publication Year	1990-
ISBN/ISSN	0925-4773
Data from Reference
Alleles (25)
	aop^ACT.Scer\UAS aop^yan-1 aos^Δ7 Ecol\lacZ^AA142 Ecol\lacZ^aos-W11 Ecol\lacZ^pnt-1277 Ecol\lacZ^Scer\UAS.cBa Ecol\lacZ^X55 Egfr^DN.Scer\UAS Egfr^f11 Jra^Asp.Scer\UAS phl¹¹ phl^{Scer\UAS.F179} pnt^P1.Scer\UAS pnt^P2.Scer\UAS pnt^{T151A.Scer\UAS} pnt^Δ88 Ras85D^e2F Ras85D^N17.Scer\UAS Ras85D^V12.Scer\UAS Ras85D^V12 Rnor\CD2^{Scer\UAS.cDBa} Scer\GAL4^sim.PS Scer\GAL4^sli.PS spi¹
Constructs (13)
	P{GAL4-sim.S} P{GAL4-sli.S} P{UAS-act-jun} P{UAS-aop.ACT} P{UAS-CD2} P{UAS-Egfr.DN} P{UAS-lacZ.B} P{UAS-phl.gof} P{UAS-pnt.P1} P{UAS-pnt.P2.T151A} P{UAS-pnt.P2} P{UAS-Ras85D.N17} P{UAS-Ras85D.V12}
Genes (12)
	aop aos Ecol\lacZ Egfr Jra phl pnt Ras85D rl Rnor\CD2 Scer\GAL4 spi
Insertions (4)
	P{lacW}pnt¹²⁷⁷ P{lwB}AA142 P{lwB}aos^W11 P{lwB}X55