Reference Report

Reference
Citation	Warmke, J.W., Reenan, R.A.G., Wang, P., Qian, S., Arena, J.P., Wang, J., Wunderler, D., Liu, K., Kaczorowski, G.J., Ploeg, L.H.T.V., Ganetzky, B., Cohen, C.J. (1997). Functional expression of Drosophila para sodium channels. Modulation by the membrane protein tipe and toxin pharmacology. J. Gen. Physiol. 110(2): 119--133. (Export to RIS)
FlyBase ID	FBrf0097720
Publication Type	Research paper
PubMed ID	9236205
PubMed Abstract	The Drosophila para sodium channel alpha subunit was expressed in Xenopus oocytes alone and in combination with tipE, a putative Drosophila sodium channel accessory subunit. Coexpression of tipE with para results in elevated levels of sodium currents and accelerated current decay. Para/TipE sodium channels have biophysical and pharmacological properties similar to those of native channels. However, the pharmacology of these channels differs from that of vertebrate sodium channels: (a) toxin II from Anemonia sulcata, which slows inactivation, binds to Para and some mammalian sodium channels with similar affinity (Kd congruent with 10 nM), but this toxin causes a 100-fold greater decrease in the rate of inactivation of Para/TipE than of mammalian channels; (b) Para sodium channels are >10-fold more sensitive to block by tetrodotoxin; and (c) modification by the pyrethroid insecticide permethrin is >100-fold more potent for Para than for rat brain type IIA sodium channels. Our results suggest that the selective toxicity of pyrethroid insecticides is due at least in part to the greater affinity of pyrethroids for insect sodium channels than for mammalian sodium channels.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	J. Gen. Physiol.
Title	Journal of General Physiology
Publication Year	1918-
ISBN/ISSN	0022-1295
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	para tipE