Reference Report

Reference
Citation	Cunniff, J., Chiu, Y.H., Morris, N.R., Warrior, R. (1997). Characterization of DnudC, the Drosophila homolog of an Aspergillus gene that functions in nuclear motility. Mech. Dev. 66(1-2): 55--68.
FlyBase ID	FBrf0098222
Type of publication	Research paper
Offprint Available	No
External Crossreferences
PubMed ID	9376324
PubMed Abstract	Nuclear migration plays a prominent role in a broad range of developmental processes. We have cloned a Drosophila gene, DnudC, encoding a protein that is evolutionarily conserved between humans and fungi. The Aspergillus homolog, nudC, is one of a group of genes required for nuclear migration. DnudC encodes a 38.5-kDa protein, and the carboxy terminal half of the protein shares 52% amino acid identity with Aspergillus nudC. We show that the structural homology between DnudC and nudC extends to the functional level since the Drosophila gene can rescue the nuclear migration defects seen in Aspergillus nudC mutants. Immunolocalization studies using antisera against DnudC reveal that the protein is localized to the cytoplasm in Drosophila ovaries and embryos. Our data suggest that the nudC genes may be components of a functionally conserved pathway involved in the regulation of nuclear motility.
Biosis	99754342
Zoological record
Associated Information
Comments
Text of personal communication
Associated files
Related Publications

Also Published As

Other Reference Information
Secondary IDs
Language of publication	English
Additional language(s) of abstract
ISBN
Place of publication
Published In
Abbreviation	Mech. Dev.
Title	Mechanisms of Development
Authors
Volume range	33-
Year range	1990-
Page range
Publisher
Place of publication	Shannon
Language of publication	English
ISBN/ISSN	0925-4773
CODEN	MEDVE6
Data from Reference
Aberrations (7)
	Df(3L)81k19 Df(3L)st-b11 Df(3L)st-g24 Df(3L)st-j7 Df(3L)st100.62 Df(3L)st4 In(3L)std11
Alleles (1)
	Int6¹⁰⁵⁴⁷
Genes (3)
	Anid\nudC Int6 nudC
Insertions (1)
	P{PZ}Int6¹⁰⁵⁴⁷