Reference Report

Reference
Citation	Li, S., Li, Y., Carthew, R.W., Lai, Z.C. (1997). Photoreceptor cell differentiation requires regulated proteolysis of the transcriptional repressor tramtrack. Cell 90(3): 469--478. (Export to RIS)
FlyBase ID	FBrf0098298
Publication Type	Research paper
PubMed ID	9267027
PubMed Abstract	The transcription repressor Tramtrack (TTK) is found in cone cells but not photoreceptor cells of the Drosophila eye. We show that down-regulation of TTK expression occurs in photoreceptor cells and is required for their fate determination. Down-regulation requires the presence of Phyllopod (PHYL), which is induced by the RAS pathway, and Seven In Absentia (SINA). Loss of either gene causes accumulation of TTK in photoreceptor cells, and TTK does not accumulate in cone cells if both PHYL and SINA are present. We report that SINA and PHYL promote ubiquitination and rapid degradation of TTK by the proteasome pathway in cell culture, and both SINA and PHYL bind to the N-terminal domain of TTK. These results argue that photoreceptor differentiation is regulated by the RAS pathway through targeted proteolysis of the TTK repressor.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Cell
Title	Cell
Publication Year	1974-
ISBN/ISSN	0092-8674
Data from Reference
Alleles (17)
	Ecol\lacZ^ttk-00219 phyl² phyl⁴ phyl^cLa phyl^hs.sev phyl^T:Ivir\HA1 Ras85D^V12.sev Scer\GAL4^GMR.PF Scer\GAL4^hs.2sev sina² sina³ sina^{Act5C.T:Hsap\MYC} sina^sev.PL ttk¹ ttk^{88.MtnA:T:Ivir\HA1} ttk^p69.Scer\UAS ttk^p88.Scer\UAS
Constructs (7)
	P{GAL4-Hsp70.sev} P{GAL4-ninaE.GMR} P{sev-phyl} P{sevRas1.V12} P{sev-sina} P{UAS-ttk.p69} P{UAS-ttk.p88}
Genes (9)
	Ecol\lacZ elav phyl Ras85D Scer\GAL4 sina T:Hsap\MYC T:Ivir\HA1 ttk
Insertions (1)
	P{PZ}ttk⁰⁰²¹⁹