Home
Reference Report
| Reference | |||
|---|---|---|---|
| Citation | Maduzia, L.L., Padgett, R.W. (1997). Drosophila MAD, a member of the smad family, translocates to the nucleus upon stimulation of the dpp pathway. Biochem. Biophys. Res. Commun. 238(2): 595--598. (Export to RIS) | ||
| FlyBase ID | FBrf0098303 | ||
| Publication Type | Research paper | ||
| PubMed ID | 9299558 | ||
| PubMed Abstract | Smads are a novel group of proteins which act to mediate signaling by members of the TGF-beta superfamily. Seven vertebrate Smad genes, which fall into three classes, have been reported. Members of the Class I Smads have been shown to bind to the cytoplasmic portion of the TGF-beta like receptors, where they become phosphorylated and translocate to the nucleus. Once in the nucleus they may function as transcriptional activators. We wondered if translocation to the nucleus is a general property of the Smads and whether it was evolutionarily conserved. We examined the subcellular localization of Drosophila MAD and found that it is capable of nuclear translocation, in Drosophila S2 cells, when the dpp pathway is stimulated. To prove the functional conservation of receptor/Smad interactions, we used the mouse BMP type I receptor ALK6 to stimulate the pathway and found that it is capable of sending MAD to the nucleus. These results show that cytoplasmic localization with translocation to the nucleus upon stimulation is a feature of the Smads that is conserved through evolution. | ||
| DOI | |||
| Related Publication(s) | |||
Recent Updates
|
|||
| Description |
What does this section display?
This section contains items that were added to this record for each release.
It currently only tracks new links between this FlyBase report and other
FlyBase data classes (e.g. genes, references, stocks) or controlled
vocabulary terms (e.g. GO, anatomy terms).
What does this section not display?
This section does not currently display links that were removed or gene model changes.
|
||
| Update Feed |
Click the icon below to subscribe to this FlyBase record and receive updates automatically through your
feed reader.
|
||
| FB2013_03 | |||
| FB2013_02 | |||
| All updates | Click here to see a list of all updates to this record from FB2010_08 and on. | ||
|
Associated Information
|
|||
| Comments | |||
| Associated Files | |||
|
Other Information
|
|||
| Secondary IDs | |||
| Language of Publication | English | ||
| Additional Languages of Abstract | |||
| Also Published As | |||
|
Parent Publication
|
|||
| Publication Type | Journal | ||
| Abbreviation | Biochem. Biophys. Res. Commun. | ||
| Title | Biochemical and Biophysical Research Communications | ||
| Publication Year | 1959- | ||
| ISBN/ISSN | 0006-291X | ||
|
Data from Reference
|
|||
| Alleles (3)
|
|||
| Genes (5)
|
|||