Reference Report

Reference
Citation	Riese, J., Tremml, G., Bienz, M. (1997). D-Fos, a target gene of Decapentaplegic signalling with a critical role during Drosophila endoderm induction. Development 124(17): 3353--3361. (Export to RIS)
FlyBase ID	FBrf0098335
Publication Type	Research paper
PubMed ID	9310330
PubMed Abstract	The Drosophila endoderm is patterned by the signals Decapentaplegic and Wingless secreted from the visceral mesoderm. This induction culminates in a precise pattern of spatially restricted expression of labial, a selector gene with a role in cell type specification in the larval midgut. Here, we show that Decapentaplegic signalling induces elevated expression of the Drosophila AP-1 transcription factor D-Fos in a slightly broader endodermal region than labial. This induction occurs in parallel to, and independently of, that of labial. Furthermore, we present evidence that D-Fos is required for labial induction in the embryo as well as for maintenance of labial expression through larval stages; and that D-Fos is critical for cellular differentiation in the larval gut. We propose that Decapentaplegic, by inducing D-Fos, broadly defines an endodermal region which thus becomes predisposed to express labial, and that D-Fos cooperates with signal-activated response factors to confer the precise pattern of labial expression in this region.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Alleles (20)
	CrebB^a.Scer\UAS CrebB^B.Scer\UAS CrebB^Cbz.Scer\UAS dpp^s4 dpp^Scer\UAS.cSa Ecol\lacZ^C5-2-7 Ecol\lacZ^lab.-6.3 Ecol\lacZ^tsh-A3-2-66 Jra^Jbz.Scer\UAS Jra^Scer\UAS.cEa kay^Fbz.Scer\UAS kay^Scer\UAS.cEa lab¹⁴ Scer\GAL4^48Y Scer\GAL4^how-24B Scer\GAL4^hs.PB shn³ wg^l-12 wg^l-17 wg^Scer\UAS.cLa
Constructs (11)
	P{Cbz} P{dCREB-2a-UAS} P{dCREB-B-UAS} P{GAL4-Hsp70.PB} P{Jbz} P{lab(-6.3)-lacZ} P{UAS-dpp.S} P{UAS-Fra.Fbz} P{UAS-Fra} P{UAS-Jra} P{UAS-wg.L}
Genes (9)
	CrebB dpp Ecol\lacZ Jra kay lab Scer\GAL4 shn wg
Insertions (4)
	P{GawB}48Y P{GawB}how^24B P{lacW}C5-2-7 P{lacW}tsh^A3-2-66