Reference Report

Reference
Citation	Martin-Morris, L.E., Csink, A.K., Dorer, D.R., Talbert, P.B., Henikoff, S. (1997). Heterochromatic trans-inactivation of Drosophila white transgenes. Genetics 147(2): 671--677. (Export to RIS)
FlyBase ID	FBrf0098841
Publication Type	Research paper
PubMed ID	9335603
PubMed Abstract	Position effect variegation of most Drosophila melanogaster genes, including the white eye pigment gene is recessive. We find that this is not always the case for white transgenes. Three examples are described in which a lesion causing variegation is capable of silencing the white transgene on the paired homologue (trans-inactivation). These examples include two different transgene constructs inserted at three distinct genomic locations. The lesions that cause variegation of white minimally disrupt the linear order of genes on the chromosomes, permitting close homologous pairing. At one of these sites, trans-inactivation has also been extended to include a vital gene in the vicinity of the white transgene insertion. These findings suggest that many Drosophila genes, in many positions in the genome, can sense the heterochromatic state of a paired homologue.
DOI
Related Publication(s)
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
Language of Publication	English
Additional Languages of Abstract
Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Genetics
Title	Genetics
Publication Year	1916-
ISBN/ISSN	0016-6731
Data from Reference
Aberrations (6)
	C(1;YL)w^mMc Df(3R)110 Df(3R)w-var3 Df(3R)Z1 In(1)w^m4 T(2;3)Ch
Alleles (7)
	Rm62^E Rm62^j3D2 Rm62^j3D5 Rm62^j14E8 Su(var)2-1¹ w^+mC w^{+mW.Scer\FRT.hs}
Constructs (2)
	P{lacW} P{RS3}
Genes (6)
	l(3)82Ca Rm62 Su(var)2-1 Su(var)205 Su(var)208 w
Insertions (7)
	P{lacW}Rm62^j3D2 P{lacW}Rm62^j3D5 P{lacW}Rm62^j14E8 P{RS3}3 P{RS3}82C-var1 P{RS3}82C-var1' P{RS3}82C-var2